Evidence map›Paper›PMID 42717050›Full record

ArticleNature chemical biology2026

Pyridoxal-phosphate-dependent biosynthesis of aminovaleramide by AvaS in tRNA.

Jingjing Sun, Junzhou Wu, Yifeng Yuan, Seetharamsing Balamkundu, Agnieszka Dziergowska, Hazel Chay Suen Suen, Dwijapriya, Cui Liang, Léo Hardy, Megan En Lee and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jingjing Sun *Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore. jingjing.sun@smart.mit.edu.ORCID http://orcid.org/0000-0002-6892-8177
Junzhou Wu *Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.ORCID http://orcid.org/0000-0002-9195-7910
Yifeng YuanDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA.
Seetharamsing BalamkunduSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Agnieszka DziergowskaInstitute of Organic Chemistry, Lodz University of Technology, Lodz, Poland.ORCID http://orcid.org/0000-0002-8888-380X
Hazel Chay Suen SuenAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.
DwijapriyaAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.
Cui LiangAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.ORCID http://orcid.org/0000-0001-9356-825X
Léo HardyEpitranscriptomic and translational responses to antibacterial stress Team, Université Paris Cité, CNRS UMR8261, Institut de Biologie Physico-Chimique, Paris, France.ORCID http://orcid.org/0009-0006-7852-4367
Megan En LeeSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Grazyna LeszczynskaInstitute of Organic Chemistry, Lodz University of Technology, Lodz, Poland.ORCID http://orcid.org/0000-0002-6874-022X
Chuan-Fa LiuSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.ORCID http://orcid.org/0000-0001-7433-2081
Zeynep BaharogluEpitranscriptomic and translational responses to antibacterial stress Team, Université Paris Cité, CNRS UMR8261, Institut de Biologie Physico-Chimique, Paris, France.ORCID http://orcid.org/0000-0003-3477-2685
Laurence DrouardInstitut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, Strasbourg, France.ORCID http://orcid.org/0000-0001-6537-524X
Steven D BrunerDepartment of Chemistry, University of Florida, Gainesville, FL, USA.
Thomas J BegleyDepartment of Biological Sciences and The RNA Institute, College of Arts and Science, University at Albany, State University of New York, New York, NY, USA.
Valérie de Crécy-LagardDepartment of Microbiology and Cell Science, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-9955-3785
Peter C DedonAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore. pcdedon@mit.edu.ORCID http://orcid.org/0000-0003-0011-3067

Funding

Linking gene and function through comparative genomic and experimental approachesR35GM156215 · NIGMS · UNIVERSITY OF FLORIDA · PI Valerie A de Crecy-Lagard · 2025 to 2026
$1.3M
Singapore-MIT Alliance for Research and Technology Centre (SMART) Antimicrobial Resistance IRGU.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM156215
6 · The paper itself

Abstract

In eubacteria, decoding of isoleucine codon AUA requires a specialized tRNA (tRNA

Identifiers

PMID42717050

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.