Evidence map›Paper›PMID 42717209›Full record

ArticleNature communications2026

Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in a mouse model for post-streptococcal encephalitis.

Charlotte R Wayne, Uğur Akcan, Travis E Faust, Violeta Durán-Laforet, Danny Jamoul, Luca Bremner, Nicole Ampatey, Büşra T Akcan, Sarah J Ho, Bogoljub Ciric and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Charlotte R Wayne *Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4622-4627
Uğur Akcan *Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Travis E FaustDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-4567-8435
Violeta Durán-LaforetDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Danny JamoulDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Luca BremnerDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Nicole AmpateyDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Büşra T AkcanDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Sarah J HoDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Bogoljub CiricDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
Shannon L DelaneyLyme and Tick-Borne Diseases Research Center, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Wendy S VargasDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Susan SwedoSection of Behavioral Pediatrics, National Institute of Mental Health, Bethesda, MD, USA.
Vilas MenonDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4096-8601
Dorothy P SchaferDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-2201-6276
Tyler CutforthDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Dritan AgalliuDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA. da191@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-5375-4143

Funding

Microglia-dependent mechanisms governing neural circuit plasticityR01MH113743 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Dorothy Patricia Schafer · 2017 to 2026
$4.9M
ADVANCED GRADUATE TRAINING PROGRAM IN NEUROBIOLOGY & BEHAVIORT32NS064928 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENGST, ULRICH · 2010 to 2024
$3.0M
Neuronal Regulation of Vascular Development and Maturation in the RetinaR01EY033994 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Dritan Agalliu · 2022 to 2026
$2.3M
How Do Synaptic Connections Change in Demyelinating Disease?R01NS117533 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA · 2021 to 2025
$2.2M
Assessing the effects of peripheral immune activation on the NVU following TBI using a vascularized and perfused human blood/BBB modelR33HL159949 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGALLIU, DRITAN, LIS, RAPHAEL · 2023 to 2025
$2.2M
Cellular and humoral immune mechanisms underlying neurovascular dysfunction in autoimmune encephalitisR01MH112849 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGALLIU, DRITAN, CUTFORTH, TYLER · 2017 to 2020
$2.1M
Assessing the effects of peripheral immune activation on the NVU following TBI using avascularized and perfused human blood/BBB model.R61HL159949 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGALLIU, DRITAN, LIS, RAPHAEL · 2021 to 2022
$1.9M
Dissecting the impact of senescence on microglia function and neurodegenerationRF1AG068281 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA, ZHANG, HONG · 2020 to 2020
$1.7M
Developing a microfluidic human neurovascular unit system to investigate genetic and age-related risk factors in Alzheimer's diseaseRF1AG078352 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGALLIU, DRITAN, SPROUL, ANDREW ALEXANDER · 2022 to 2024
$1.4M
Dissecting the impact of senescence on microglia function and neurodegenerationR01AG068281 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA, ZHANG, HONG · 2024 to 2024
$419k
Th17 cell-mediated CNS damage in response to recurrent S. pyogenes intranasal infectionsR56MH109987 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGALLIU, DRITAN, CUTFORTH, TYLER · 2016 to 2016
$400k
Alzheimer's Association AARF-22-923219BrightFocus Foundation (BrightFocus) A2022006FNEI NIH HHS R01 EY033994NHLBI NIH HHS R33 HL159949NHLBI NIH HHS R61 HL159949NIA NIH HHS R01 AG068281NIA NIH HHS RF1 AG068281NIA NIH HHS RF1 AG078352NIMH NIH HHS R01 MH112849NIMH NIH HHS R01 MH113743NIMH NIH HHS R56 MH109987NINDS NIH HHS R01 NS117533NINDS NIH HHS T32 NS064928U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R01EY033994U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R61HL159949, R33HL159949U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH112849, 56MH109987U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH113743U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 2T32NS064928U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS117533U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) RF1AG068281, R01AG068281U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) RF1AG078352
6 · The paper itself

Abstract

Group A Streptococcus (GAS) infections cause neuropsychiatric complications in children, but the mechanisms linking peripheral infection to brain dysfunction remain unclear. Using mouse genetics, single-cell RNA sequencing, and spatial transcriptomics, we show that GAS infections induce inflammatory transcriptional programs in microglia and brain endothelial cells (BECs), accompanied by loss of blood-brain barrier (BBB) gene expression in female mice. Spatial transcriptomic analyses reveal that GAS-responsive microglia localize near infiltrating CD4

Indexed as

CytokinesEncephalitisEndothelial CellsMicrogliaStreptococcal InfectionsTh17 CellsAnimalsBlood-Brain BarrierBrainChemokinesDisease Models, AnimalFemaleGranulocyte-Macrophage Colony-Stimulating FactorHumansInterleukin-17MiceChemokinesCytokinesGranulocyte-Macrophage Colony-Stimulating FactorIl17a protein, mouseIl17ra protein, mouseInterleukin-17Receptors, Interleukin-17

Identifiers

PMID42717209
PMCPMC13558752

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.