Evidence map›Paper›PMID 42717329›Full record

ArticleBMC psychiatry2026

Transdiagnostic child mental health trajectories in Japan: protocol for a nationwide web‑based open cohort study.

Takashi Yamada, Kohei Kurita, Tomoko Nishimura, Makoto Fujii, Arika Yoshizaki, Tomoka Yamamoto, Yoshiko Iwatani, Ikuko Hirata, Eiko Honaga, Ryo Kimura and 8 more

Abstract read
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In one paragraph

Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Takashi YamadaUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan. yamada.takashi.ugscd@osaka-u.ac.jp.
Kohei KuritaUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Tomoko NishimuraUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Makoto FujiiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.
Arika YoshizakiMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Osaka, Japan.
Tomoka YamamotoUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Yoshiko IwataniUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Ikuko HirataUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Eiko HonagaDepartment of Psychiatry, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.
Ryo KimuraUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Masaya TachibanaUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Ikuko MohriUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Ryo KawasakiDivision of Public Health, Department of Social Medicine, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.
Masayuki EndoDivision of Health Science, Department of Children and Women's Health, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.
Nagahide TakahashiDepartment of Intellectual and Developmental Disabilities, National Center of Neurology and Psychiatry (National Research and Development Agency), Kodaira, Tokyo, Japan.
Taiichi KatayamaUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Kenji J TsuchiyaUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Kuriko Kagitani-ShimonoUnited Graduate School of Child Development, The University of Osaka, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Japan 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreventive psychiatry requires longitudinal, transdiagnostic data from before adolescence, yet such data are scarce. We propose a nationwide, digital, open cohort in Japan to track mental health trajectories from birth to late adolescence using multi-informant assessments (caregivers and adolescents) within a transdiagnostic, biopsychosocial framework. Diagnosis-open recruitment will combine community-facing dissemination with clinically linked neurodevelopmental enrichment (e.g. autism spectrum disorder and attention-deficit/hyperactivity disorder), addressing underrepresentation of neurodivergent children and adolescents alongside neurotypical peers. An optional saliva sub-cohort will support genetic and epigenetic analyses. This design will characterize risk and protective factors and their developmental timing to inform stage-specific prevention and early intervention.

methodsFrom February 2026, approximately 7,000 children and caregivers (up to ~14,000 individuals) will be recruited nationwide from community and clinical settings into a longitudinal online cohort. Eligible participants are caregivers aged ≥ 18 years of children and adolescents aged 0-18 years; adolescents aged 13-18 years will also complete self-reports. Enrollment and annual follow-ups will use a secure web platform integrated with LINE, a widely used communication app in Japan. Validated questionnaires will annually assess mental health and development: caregivers report on all children, and adolescents provide self-reports. The principal repeated transdiagnostic outcome is the caregiver-reported Strengths and Difficulties Questionnaire (SDQ) Total Difficulties score across ages 2-18 years. Adolescent self-reported scores will be analyzed as complementary informant-specific secondary outcomes. Longitudinal mixed-effects models will examine developmental changes and associations with risk and protective factors, with exploratory genetic and epigenetic analyses. DISCUSSION: This large longitudinal cohort will generate insights into child and adolescent mental health trajectories in Japan. Following participants from infancy through adolescence will help identify early risk and resilience indicators across traditional diagnoses. Integrating multi-informant surveys with genetic and epigenetic data will clarify how biological, psychological, and social factors interact over time. Nationwide digital recruitment aims to broaden geographic reach and reduce burden; representativeness will be empirically evaluated and findings interpreted cautiously. Results will inform the timing and targets of stage-specific preventive and early interventions in community and clinical settings.

trial registrationJapan Registry of Clinical Trials (jRCT), jRCT1050250205. Registered on 26 January 2026.

Indexed as

Autism Spectrum DisorderMental HealthAdolescentAttention Deficit Disorder with HyperactivityChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornInternetJapanLongitudinal StudiesMaleResearch DesignChild and adolescent mental healthDigital health / Web-based cohortEarly childhood developmentLongitudinal cohort studyNeurodevelopmental disordersPreventive psychiatryTransdiagnostic approach

Identifiers

PMID42717329
PMCPMC13560258

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.