ArticleBMC veterinary research2026
Isolation of feline-derived scFvs against the VP1-CDE region of feline calicivirus from a phage display library and characterization of their antigen-binding and antiviral potential in vitro.
Article in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFeline calicivirus (FCV) is a significant causative pathogen of upper respiratory tract disease and virulent systemic infection in feline populations, yet specific targeted antiviral agents for FCV infection remain unavailable.
methodsA feline-derived single-chain variable fragment (scFv) phage display library targeting the VP1-CDE neutralizing region of FCV was constructed using peripheral blood mononuclear cells isolated from cats immunized with recombinant VP1-CDE protein. Positive scFv clones were screened via three rounds of affinity panning and phage ELISA. The scFv-Fc fusion proteins were expressed in eukaryotic cells, and their antigen-binding properties and antiviral potential were characterized through Western blotting, bio-layer interferometry, immunofluorescence assay and viral neutralization assay.
resultsThe constructed library reached a size of 2.1 × 10
conclusionsscFv-Fc-3A5 and scFv-Fc-2H5 are promising candidate molecules for the development of diagnostic reagents and antiviral therapeutics targeting genogroup II FCV.
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