Evidence map›Paper›PMID 42717569›Full record

ArticleMicrobiologyOpen2026

Nanoemulsification Promotes Antibacterial Activity of Selected Essential Oils Against Multidrug-Resistant Staphylococcus aureus Biofilms In Vitro.

Sumeena Karki, Mahnaz Ramezanpour, Clare M Cooksley, Emma Barry, Clive A Prestidge, Roshan Nepal, Sholeh Feizi, Dianne Correll, Peter-John Wormald, Sarah Vreugde and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sumeena KarkiSchool of Medicine, College of Health, Adelaide University, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0001-8026-7108
Mahnaz RamezanpourSchool of Medicine, College of Health, Adelaide University, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0001-6218-2071
Clare M CooksleySchool of Medicine, College of Health, Adelaide University, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0003-3109-4540
Emma BarrySchool of Medicine, College of Health, Adelaide University, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0003-2742-5650
Clive A PrestidgeCentre of Pharmaceutical Innovation, School of Pharmacy and biomedical Sciences, Adelaide University, Adeliade, South Australia, Australia.
Roshan NepalThe Commonwealth Scientific and Industrial Research Organisation, Hobart, Tasmania, Australia.ORCID https://orcid.org/0000-0002-5469-3397
Sholeh FeiziSchool of Medicine, College of Health, Adelaide University, Adelaide, South Australia, Australia.
Dianne CorrellWild Wood Oils of Australia, Angaston, South Australia, Australia.
Peter-John WormaldSchool of Medicine, College of Health, Adelaide University, Adelaide, South Australia, Australia.
Sarah VreugdeSchool of Medicine, College of Health, Adelaide University, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0003-4719-9785
Muhammed AwadSchool of Medicine, College of Health, Adelaide University, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0002-0402-6406

Funding

Australian Centre for International Agriculture ResearchRARA Biotech Pvt. Ltd.
6 · The paper itself

Abstract

Essential oils (EOs) are unique materials with healing powers that have been extensively reported. Yet their full antimicrobial potential is still underexplored due to their complex molecular properties, high viscosity, and low solubility, which limit their wide pharmaceutical application. In this study, we report the formulation of water-soluble nanoemulsions (NEs) of three EOs, namely, Artemisia vulgaris, Rhododendron anthopogon, and Eremophila mitchellii. The prepared NEs had an average particle diameter between 190 and 230 nm and remained physically stable at 4°C for up to 6 months. Most importantly, the fabricated NEs enhanced the antibacterial activity of the EOs against a multidrug-resistant Staphylococcus aureus clinical isolate by eightfold, with the EO having a median minimum inhibitory concentration (MIC) of 64 mg/mL, whilst the NEs had a median value of 8 mg/mL. Moreover, the NEs reduced the biofilm viability by up to > 6 log

Indexed as

Anti-Bacterial AgentsBiofilmsMethicillin-Resistant Staphylococcus aureusOils, VolatileStaphylococcus aureusArtemisiaDrug Resistance, Multiple, BacterialEmulsionsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsEmulsionsOils, Volatileantimicrobial activityArtemisia vulgarisEremophila mitchelliinanoemulsionRhododendron anthopogonStaphylococcus aureus

Identifiers

PMID42717569
PMCPMC13559023

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.