Evidence map›Paper›PMID 42717650›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2026

The Role of Arp2/3 in End-Resection During DNA Double-Strand Break Repair.

Felix Y Zhou, James E Haber

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Felix Y ZhouRosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts, USA.
James E HaberRosenstiel Center and Department of Biology, Brandeis University, Waltham, Massachusetts, USA.

Funding

DNA Damage Response and Repair of a Broken ChromosomeR35GM127029 · NIGMS · BRANDEIS UNIVERSITY · PI JAMES E HABER · 2018 to 2026
$8.6M
NIGMS NIH HHS R35 GM127029
6 · The paper itself

Abstract

The efficient repair of chromosome breaks by homologous recombination depends on the ability of the ends of a double-strand break (DSB) to locate homologous sequences to serve as templates to repair the lesion. These repair mechanisms are conserved across eukaryotic evolution. Repair depends on 5' to 3' resection of the broken ends, allowing the assembly of a Rad51 filament. In yeast, fruit flies, and mammals, broken chromosome ends display increased mobility, allowing the ends to explore a larger volume. The Arp2/3 actin nucleator complex plays a key role in increased local chromatin mobility near a DSB. In budding yeast, Arp2/3, LAS17

Indexed as

Actin-Related Protein 2-3 ComplexDNA Breaks, Double-StrandedDNA RepairAnimalsChromatinHomologous RecombinationHumansRad51 RecombinaseSaccharomyces cerevisiaeActin-Related Protein 2-3 ComplexChromatinRad51 Recombinasebiologycell biologychromatinDNADNA damageDNA repairhomologous recombinationRad51

Identifiers

PMID42717650
PMCPMC13559217

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.