Evidence map›Paper›PMID 42717832›Full record

ArticleRenal failure2026

Kidney injury associated with direct oral anticoagulants: a comparative study of direct thrombin inhibitors and factor Xa inhibitors based on literature and database analysis.

Songhua Chen, Can Shi, Xiang Li, Xia Wang, Ren Guo, Tian Wu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Songhua ChenDepartment of Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.
Can ShiDepartment of Radiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Xiang LiDepartment of Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.
Xia WangDepartment of Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.
Ren GuoDepartment of Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.
Tian WuDepartment of Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While direct oral anticoagulants (DOACs) are widely used, limited real-world studies have explored kidney injury linked to DOACs, particularly differences between direct thrombin inhibitors (DTIs) and factor Xa inhibitors (FXaIs). We conducted a comprehensive analysis of kidney injury cases from the FDA Adverse Event Reporting System (FAERS, 2008-2024) and systematically reviewed published case reports, comparing DTIs (dabigatran) with FXaIs (rivaroxaban, apixaban, edoxaban). Among 8,116 reports of suspected DOAC-associated kidney injury, 1,784 were linked to DTIs and 6,332 to FXaIs. Significant reporting rates were observed for DTIs [reporting odds ratio (ROR) = 2.081, 95% CI: 1.979-2.189; proportional reporting ratio (PRR) = 2.044, CI: 1.947-2.147)] and FXaIs (ROR = 1.483, 95% CI: 1.444-1.523; PRR = 1.472, CI: 1.434-1.510). Notably, substantial intra-class variation existed among FXaIs, with edoxaban showing the highest risk signal (ROR = 4.453, 95% CI: 4.021-4.932; PRR = 4.212, 95% CI: 3.831-4.632). Multivariable logistic regression analysis confirmed that significantly lower kidney injury reporting disproportionality signals with FXaIs versus DTIs after adjustment (ROR = 0.687, 95% CI: 0.650-0.727,

Indexed as

Acute Kidney InjuryAnticoagulantsAntithrombinsFactor Xa InhibitorsAdministration, OralAdverse Drug Reaction Reporting SystemsDabigatranDatabases, FactualHumansPyrazolesPyridinesPyridonesRivaroxabanThiazolesUnited StatesAnticoagulantsAntithrombinsapixabanDabigatranedoxabanFactor Xa InhibitorsPyrazolesPyridinesPyridonesRivaroxabanThiazolesDirect oral anticoagulantsdirect thrombin inhibitorsfactor Xa inhibitorskidney injury

Identifiers

PMID42717832
PMCPMC13564161

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.