Evidence map›Paper›PMID 42717866›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2026

Sexually Dimorphic Role of Estrogen Receptor α in Preserving Right Ventricular Endothelial Integrity.

Jiajun Li, Vijaya Karoor, Andrea L Frump, Hanqiu Zhao, Shunning Liang, Chen-Shan Chen Woodcock, Irina Petrache, Zhiyu Dai, Tim Lahm

Abstract read
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In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jiajun LiDepartment of Pharmacology and Molecular Medicine (J.L.), University of Colorado, Anschutz Medical Campus, Aurora.ORCID 0000-0003-2661-0950
Vijaya KaroorDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine (V.K., I.P., T.L.), University of Colorado, Anschutz Medical Campus, Aurora.
Andrea L FrumpDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis (A.L.F.).ORCID 0000-0002-5972-5079
Hanqiu ZhaoDivision of Pulmonary Critical Care and Medicine, Department of Medicine, Washington University School of Medicine in St. Louis, MO (H.Z., S.L., Z.D.).
Shunning LiangDivision of Pulmonary Critical Care and Medicine, Department of Medicine, Washington University School of Medicine in St. Louis, MO (H.Z., S.L., Z.D.).ORCID 0009-0000-8915-4548
Chen-Shan Chen WoodcockDivision oficine, Department of Medicine, National Jewish Health, Denver, CO (J.L., C.-S.C.W., I.P., T.L.).ORCID 0000-0003-4291-1788
Irina PetracheDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine (V.K., I.P., T.L.), University of Colorado, Anschutz Medical Campus, Aurora.ORCID 0000-0003-1094-2600
Zhiyu DaiDivision of Pulmonary Critical Care and Medicine, Department of Medicine, Washington University School of Medicine in St. Louis, MO (H.Z., S.L., Z.D.).ORCID 0000-0002-2945-7923
Tim LahmDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine (V.K., I.P., T.L.), University of Colorado, Anschutz Medical Campus, Aurora.ORCID 0000-0003-0007-6606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRight ventricular (RV) adaptation to increased afterload determines survival in pulmonary hypertension (PH) and is sexually dimorphic and more preserved in females, mediated in part by protective ERα (estrogen receptor α) signaling in cardiomyocytes. However, effects of ERα on RV endothelial cells (RVECs), a critical mediator of RV adaptation, are unknown. We hypothesized that ERα exerts sexually dimorphic proangiogenic effects on RVECs in vitro and in vivo.

methodsWe isolated RVECs from male and female rats with an ERα

resultsCompared with cells isolated from wild-type animals, RVECs from male and female ERα

conclusionsERα exhibits a sex-specific endothelial-intrinsic role that is essential for RV angiogenesis under both homeostatic and pathological conditions. This effect appears to stem from enhanced survival and migration capacity of capillary and endocardial RVECs. ERα may be a potential target for sex-specific RV-directed therapies in PH.

Indexed as

angiogenesisapoptosisendothelial cellshypertension, pulmonaryreceptors, estrogen

Identifiers

PMID42717866

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.