Evidence map›Paper›PMID 42718625›Full record

ArticleMaterials today. Bio2026

In situ-built chemo-electroactive hydrogel incorporating Mg-based hydrogen generators for osteoarthritis therapy.

Hongyu Zhong, Qi He, Fang Qin, Yao Shu, Yijian Wang, Xiang Yang, Zhonghao Chen, Sheng Yao, Chuxuan Gui, Jing Xiang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hongyu ZhongYouth Orthopedic Surgery, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, The Third School of Clinical Medicine, Southern Medical University, No. 183, Zhongshan Avenue West, Guangzhou, 510630, China.
Qi HeExperimental Education/Administration Center, National Demonstration Center for Experimental Education of Basic Medical Sciences, Key Laboratory of Functional Proteomics of Guangdong Province, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Fang QinSchool of Nursing, Southern Medical University, Guangzhou, 510515, China.
Yao ShuYouth Orthopedic Surgery, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, The Third School of Clinical Medicine, Southern Medical University, No. 183, Zhongshan Avenue West, Guangzhou, 510630, China.
Yijian WangYouth Orthopedic Surgery, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, The Third School of Clinical Medicine, Southern Medical University, No. 183, Zhongshan Avenue West, Guangzhou, 510630, China.
Xiang YangNanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China.
Zhonghao ChenSchool of Biomedical Engineering, Guangdong Provincial Key Laboratory of Medical Image Processing, Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, 510515, China.
Sheng YaoSchool of Biomedical Engineering, Guangdong Provincial Key Laboratory of Medical Image Processing, Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, 510515, China.
Chuxuan GuiNanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China.
Jing XiangExperimental Education/Administration Center, National Demonstration Center for Experimental Education of Basic Medical Sciences, Key Laboratory of Functional Proteomics of Guangdong Province, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Lu LiuPharmacy Department, The Fifth Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510900, China.
Yun ChenYouth Orthopedic Surgery, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, The Third School of Clinical Medicine, Southern Medical University, No. 183, Zhongshan Avenue West, Guangzhou, 510630, China.
Yingfeng TuState Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Kun LiuExperimental Education/Administration Center, National Demonstration Center for Experimental Education of Basic Medical Sciences, Key Laboratory of Functional Proteomics of Guangdong Province, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Jinghui YaoYouth Orthopedic Surgery, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, The Third School of Clinical Medicine, Southern Medical University, No. 183, Zhongshan Avenue West, Guangzhou, 510630, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a degenerative disease, osteoarthritis (OA) is critically influenced by inflammation and extracellular matrix (ECM) degradation in the repair of articular cartilage. Though the in-situ hydrogel could alleviate joint pain with high patient compliance, the synergetic management of the pathological progression of osteoarthritis is limited. Herein, a microenvironment-responsive chemo-electroactive hydrogel is designed by integrating asymmetric magnesium hydrogen generators (MHG) and black phosphorus nanosheets (BPNS) within a biomimetic double-network matrix (PHO) for cartilage repair. The MHG and BPNS couple to form a micro-galvanic cell, where MHG provides electrons and BPNS acts as a low-impedance heterogeneous cathode, establishing a stable microcurrent field. The biomimetic double-network not only provides PHO-MHG@BP with excellent injectability and self-healing ability, but also triggers intelligent release of H

Indexed as

Anti-inflammationChemo-electroactive hydrogelMg-based hydrogen generatorOsteoarthritis therapyROS scavenging

Identifiers

PMID42718625
PMCPMC13553581

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.