ArticleFrontiers in public health2026
Nutritional risk, cold exposure, and stroke severity in older adults: an exploratory analysis of the "collapsed furnace" hypothesis.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the exploratory "Collapsed Furnace" hypothesis that nutritional depletion and sarcopenia-related frailty may alter responses to ambient cold in older adults with stroke. Methods: We integrated Global Burden of Disease (GBD) 2023 estimates for China (1990-2021), exploratory physiological data from the China Health and Retirement Longitudinal Study (CHARLS) 2015, and a retrospective clinical stroke cohort. The primary clinical analysis included patients aged ≥70 years; the full cohort aged ≥67 years was retained for sensitivity analysis. Nutritional risk was assessed using admission serum albumin as a nutritional-inflammatory marker, with the body mass index (BMI)-adjusted modified Geriatric Nutritional Risk Index (mGNRI) used as a sensitivity measure. Multivariable models examined nutritional risk, cold exposure, and their interaction in relation to admission National Institutes of Health Stroke Scale (NIHSS) score, adjusting for prespecified demographic, vascular, lifestyle, stroke-type, BMI, and C-reactive protein (CRP) covariates. Results: Sodium-attributable stroke burden peaked at ages 70-79 years, whereas cold-attributable burden increased in the oldest groups. In the GBD analysis, the malnutrition × low-temperature interaction was negative ( Conclusion: Nutritional depletion was strongly associated with stroke severity, but its role in modifying cold-related vulnerability remains uncertain. Because the clinical interaction was not significant and mortality, pre-stroke albumin, individual cold exposure, and core temperature were unavailable, the proposed ceiling-like effect should be considered hypothesis-generating and requires prospective validation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.