ArticleFrontiers in digital health2026
Photoplethysmography acceleration indices as digital biomarkers of cardiometabolic health.
Article in Frontiers in digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Non-invasive monitoring of cardiovascular health is critical for early detection of dysfunction. Photoplethysmography (PPG) is already widely used in wearable devices to track cardiovascular signals, such as heart rate and pulse wave characteristics. The second derivative of the PPG signal, known as the accelerated plethysmogram (APG), provides indices reflecting arterial stiffness and vascular aging. Despite their potential as digital biomarkers, systematic comparisons across clinical populations are limited. In this cross-sectional study, four APG-derived indices (b/a, c/a, d/a, AGI) were analyzed in 133 participants: healthy individuals (
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