Evidence map›Paper›PMID 42718842›Full record

ArticleFrontiers in endocrinology2026

Longitudinal evaluation of glomerular filtration rate across adolescence and early adulthood in youth with type 1 diabetes: associations with clinical and social risk factors.

Antoine B M Clarke, Jacqueline R Curtis, Yesmino T Elia, Paul Benitez-Aguirre, Fergus J Cameron, Scott T Chiesa, Cheril Clarson, Jennifer J Couper, Maria E Craig, R Neil Dalton and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01581476. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01581476 phase3completed

Randomised, Double Blind, Placebo Controlled Trial of Angiotensin Converting Enzyme Inhibitors and Statins in the Prevention of Long Term Complications in Young People With Type 1 Diabetes

Ran2009Enrolled443Registered outcomes5Posted comparisons0ConditionsType 1 DiabetesArmsACE inhibitor, Combination therapy, Placebo, Statin
PMID 20017932PMID 22416821PMID 18349042PMID 17257274other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Antoine B M ClarkeDivision of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Jacqueline R CurtisDivision of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Yesmino T EliaDivision of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Paul Benitez-AguirreInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, University of Sydney, Westmead, NSW, Australia.
Fergus J CameronDepartment of Paediatrics, University of Melbourne, Parkville, VIC, Australia.
Scott T ChiesaInstitute of Cardiovascular Science, University College London, London, United Kingdom.
Cheril ClarsonChildren's Hospital, London Health Sciences Center, London, ON, Canada.
Jennifer J CouperDiabetes and Endocrinology Department, Women's and Children's Hospital, North Adelaide, SA, Australia.
Maria E CraigDepartment of Paediatrics, University of Melbourne, Parkville, VIC, Australia.
R Neil DaltonEvelina London Children's Hospital, Guy's and St Thomas' National Health Service Foundation Trust, London, United Kingdom.
Elizabeth A DavisDepartment of Endocrinology and Diabetes, Perth Children's Hospital, Nedlands, WA, Australia.
Sally M MarshallDiabetes Research Group, Translational and Clinical Research Institute, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
David Z I CherneyDivision of Nephrology, University Health Network and University of Toronto, Toronto, ON, Canada.
M Loredana MarcovecchioDepartment of Paediatrics, University of Cambridge, Cambridge, United Kingdom.
Farid H MahmudDivision of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The continuous evaluation of GFR among youth with T1D has traditionally been difficult during the transition to adult care given distinct pediatric & adult estimated GFR (eGFR) formulas recommended by clinical practice guidelines. We aimed to assess longitudinal trends in kidney function in type 1 diabetes from adolescence to early adulthood using updated eGFR formulae and to examine associations between eGFR and clinical as well as social factors over time in this population. Methods: Clinical factors including age, sex, diabetes duration, insulin therapy, BMI and HbA1c in addition to social factors including ethnicity & material deprivation (MD) were collected alongside creatinine (Cr) and cystatin c (CysC) from Canadian participants in the AdDIT & CanSOLVE CKD-SPOR studies (2009-2023). Estimated glomerular filtration rates (eGFR) derived using updated Chronic Kidney Disease in Children under 25 (CKiD U25) Cr, CysC & combined Cr-CysC formulas were evaluated longitudinally using linear mixed effects regression, as were urine albumin-creatinine ratios (uACR). Results: Youth with type 1 diabetes ages 10 to <25 years were evaluated (N = 137) at a median 5 timepoints (IQR: 4-6) over 9.8 ± 1.3 years. As age increased, eGFR Conclusions: Different eGFR trends were observed using Cr- vs. CysC-derived estimates in youth with diabetes using updated eGFR formulae. Elevations in eGFR, alongside alterations in markers of albuminuria, were associated with increased glycemia and marginalization, providing insights into key clinical and social risk factors for kidney disease monitoring in this population. (NCT01581476).

Indexed as

Diabetes Mellitus, Type 1Diabetic NephropathiesGlomerular Filtration RateAdolescentAdultCanadaChildClinical Trials, Phase III as TopicCreatinineCystatin CFemaleGlycated HemoglobinHumansLongitudinal StudiesMaleMulticenter Studies as TopicCreatinineCystatin CGlycated Hemoglobinestimated GFRkidney functionlongitudinalpediatrictransition to adult care

Identifiers

PMID42718842
PMCPMC13553482

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.