Evidence map›Paper›PMID 42718968›Full record

ArticleFrontiers in aging neuroscience2026

Association of the hsCRP- triglyceride-glucose index (CTI) with early infarct growth rate in acute ischemic stroke due to large artery occlusion.

Haiping Tang, Guojun He, Lei Li, Shuangfei You, Deming Li, Songjie Chen, Yan Guo, Yongqing Cheng, Shifu Sun

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Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Haiping Tang *Department of Neurology, Binghai County People's Hospital, Yancheng, Jiangsu, China.
Guojun He *Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Lei LiDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Shuangfei YouDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Deming LiDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Songjie ChenDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Yan GuoDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Yongqing ChengDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Shifu SunDepartment of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Rapid infarct growth in acute ischemic stroke (AIS) due to large artery occlusion (LAO) is associated with poor clinical outcomes despite successful recanalization. The hypersensitive C-reactive protein (hsCRP)-triglyceride-glucose (TyG) index (CTI), a novel biomarker integrating insulin resistance and systemic inflammation, may reflect a meta-inflammatory state that exacerbates ischemic injury. However, its relationship with early infarct growth rate (IGR) remains unexplored. This study aimed to investigate whether CTI is independently associated with early IGR in patients with anterior circulation LAO. Methods: We conducted a prospective cross-sectional study of 247 patients with AIS due to anterior circulation LAO. CTI was calculated as the product of the TyG index and high-sensitivity CRP from fasting blood samples. Early IGR was defined as the baseline infarct core volume (rCBF <30%) divided by the time from symptom onset to imaging. Patients were categorized into fast (≥10 mL/h) or slow (<10 mL/h) IGR groups. Multivariable logistic regression was used to assess the independent association between CTI and fast IGR. Results: The fast IGR group had significantly higher CTI levels (median 5.396 vs. 5.177, Conclusion: Elevated CTI is independently associated with faster early infarct growth in LAO stroke, suggesting its potential role as an adjunctive biomarker that may complement clinical and imaging assessment for risk stratification. However, the modest discriminative performance (AUC = 0.613) underscores the need for integration with established predictors rather than standalone use.

Indexed as

acute ischemic strokebiomarkerhsCRP-triglyceride-glucose indexinfarct growth ratelarge artery occlusion

Identifiers

PMID42718968
PMCPMC13553777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.