Evidence map›Paper›PMID 42719094›Full record

ArticleFrontiers in public health2026

Clinical characteristics and prognostic factors in non-HIV patients with

Chaomin Guo, Yajiao An, Jingyun Ye, Yanning Ma, Qiang Zhao, Lifeng Wang, Wei Ma, Mingze Zhang, Miaoyu Wang, Yang Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chaomin Guo *Laboratory Medicine Department, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Yajiao An *Laboratory Medicine Department, Cengong County People's Hospital, Guizhou, China.
Jingyun Ye *Laboratory Medicine Department, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Yanning MaLaboratory Medicine Department, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Qiang ZhaoLaboratory Medicine Department, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Lifeng WangLaboratory Medicine Department, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Wei MaLaboratory Medicine Department, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Mingze ZhangDepartment of Gynaecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Miaoyu WangDepartment of Pulmonary and Critical Care Medicine, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Yang WangLaboratory Medicine Department, Hainan Branch, Chinese PLA General Hospital, Sanya, Hainan, China.
Jiyong YangLaboratory Medicine Department, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Liyan YeLaboratory Medicine Department, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Liuyang YangLaboratory Medicine Department, The First Medical Center, Chinese PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: In this single-center retrospective cohort study, we enrolled 62 non-HIV patients with confirmed PJP between 2019 and 2023. BALF CMV co-detection was defined as detectable CMV DNA in bronchoalveolar lavage fluid via metagenomic next-generation sequencing (mNGS), combined with compatible respiratory symptoms and chest computed tomography abnormalities. The Benjamini-Hochberg false discovery rate (FDR) correction was applied for multiple comparisons. Results: Overall, 31 patients (50.0%) had BALF CMV co-detection. The 28-day all-cause mortality was significantly higher in the CMV co-detection group than in the PJP-only group (54.84% vs. 19.35%, Conclusion: In this single-center retrospective cohort, BALF CMV co-detection is associated with substantially elevated unadjusted 28-day mortality in non-HIV patients with PJP. These findings are hypothesis-generating; IL-6, PCT and D-dimer show potential as exploratory prognostic markers. Comprehensive mNGS-based pathogen screening combined with biomarker monitoring may facilitate risk stratification in this high-risk population, pending validation in larger prospective cohorts.

Indexed as

Bronchoalveolar Lavage FluidCoinfectionCytomegalovirusCytomegalovirus InfectionsPneumocystis cariniiPneumonia, PneumocystisFemaleHumansMaleMiddle AgedPrognosisRetrospective Studiesco-detectioncytomegalovirusmetagenomic next-generation sequencingnon-HIV immunocompromised patientsPneumocystis jirovecii pneumoniaprognostic biomarkersretrospective cohort study

Identifiers

PMID42719094
PMCPMC13553864

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.