ReviewJournal of ginseng research2026
Nrf2 as a therapeutic target of ginseng: A comprehensive review from preclinical evidence to clinical applications.
Review in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Ginseng is a traditional herb that has been widely used for centuries to treat various diseases. A key mechanism of ginseng is the activation of nuclear factor erythroid 2-like 2 (Nrf2), a master regulator of antioxidant gene expressions. Activation of Nrf2 helps maintain redox homeostasis, which is crucial for chronic disease management. This review aims to summarize the pleiotropic role of Nrf2 in mediating the biological effects of bioactive compounds, extracts, and formulations of ginseng. It provides a comprehensive overview of current research on the medicinal applications of ginseng for treating various diseases and highlights the mechanisms involved in Nrf2 regulation. The literature published from 2018 to 2025 were reviewed using a PubMed search to assess recent studies on the therapeutic applications of ginseng mediated by Nrf2. Ginseng activates the Nrf2 signaling pathway and modulates its upstream signaling, including Kelch-like ECH-associated protein 1 (Keap1), p62, and glycogen synthase kinase-3β (GSK-3β). It exhibits anti-oxidative stress, anti-inflammation, anti-apoptosis, anti-ferroptosis, and anti-pyroptosis properties in both
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