ArticleJournal of biomedical optics2026
Biomechanical assessments of high-fluence corneal cross-linking with supplemental oxygen using optical coherence elastography in
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Significance: Epithelium-off corneal collagen cross-linking (CXL) has drawbacks related to epithelial removal. Earlier epithelium-on approaches without supplemental oxygen showed limited efficacy due to inadequate permeation of the photoenhancer and oxygen into the corneal stroma. Improved epithelium-on CXL with improved photoenhancer permeation and supplemental oxygen has demonstrated effective cross-linking in two phase 3 trials. Aim: The study aims to evaluate the effect of supplemental oxygen during epithelium-on CXL in an Approach: Epithelium-on CXL was performed on two groups of Results: Forty eyes treated under hyperoxic conditions and pulsed illumination exhibited a statistically significant greater increase ( Conclusions: These results strongly suggest that the use of supplemental oxygen during epithelium-on CXL produces stronger inter-corneal collagen cross-links and greatly improves corneal stiffness, potentially lessening or preventing the risk of vision loss for patients with keratoconus.
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