Evidence map›Paper›PMID 42719581›Full record

ReviewStem cells international2026

Mechanisms of Mesenchymal Stem Cell-Derived Exosomes in Dry Eye Disease: From Inflammation Pathways to Therapeutic Prospects.

Jiahuan Yi, Fangfang Lu, Yale Tian, Yu Wang, Zihe Zhang, Xujie Deng, Zhi Wang, Shigang Xia, Jia Zhang, Qiguo Xiao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiahuan YiDepartment of Ophthalmology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China, usc.edu.cn.ORCID https://orcid.org/0009-0004-6875-3452
Fangfang LuDepartment of Ophthalmology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China, usc.edu.cn.ORCID https://orcid.org/0000-0002-9214-3046
Yale TianDepartment of Ophthalmology Cardiovascular Internal Medicine, Hunan Normal University Affiliated Hengyang City Central Hospital, Hengyang 421001, Hunan, China.ORCID https://orcid.org/0000-0002-1215-6155
Yu WangDepartment of Ophthalmology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China, usc.edu.cn.
Zihe ZhangDepartment of Ophthalmology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China, usc.edu.cn.ORCID https://orcid.org/0009-0007-3454-1357
Xujie DengDepartment of Ophthalmology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China, usc.edu.cn.ORCID https://orcid.org/0009-0006-2728-042X
Zhi WangDepartment of Ophthalmology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China, usc.edu.cn.ORCID https://orcid.org/0000-0001-9202-4250
Shigang XiaDepartment of Ophthalmology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China, usc.edu.cn.ORCID https://orcid.org/0009-0009-3172-8671
Jia ZhangDepartment of Ophthalmology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China, usc.edu.cn.ORCID https://orcid.org/0000-0001-7190-3993
Qiguo XiaoDepartment of Ophthalmology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China, usc.edu.cn.ORCID https://orcid.org/0000-0002-0263-2138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry eye disease (DED) is a chronic ocular surface disorder triggered by tear film imbalance, in which inflammatory disruption of immune homeostasis constitutes the core pathological mechanism. Mesenchymal stem cell-derived exosomes (MSC-Exos) offer promising anti-inflammatory therapeutic potential through immune modulation, tissue repair, and their inherently low immunogenicity. This review elucidates MSC-Exos' molecular regulation of DED inflammation, demonstrating their suppression of the TLR4/NF-κB signaling axis, the IRAK1/TRAF6/NF-κB cascade reaction, the STAT3 transcriptional regulatory network, and the NLRP3 inflammasome activation pathway, while revealing a synergistic mechanism through which MSC-Exos ameliorate the ocular surface inflammatory microenvironment by modulating the Th17/Treg immune balance via the gut-eye axis and facilitating FBXW7-mediated ubiquitination degradation pathways. Despite this therapeutic potential, clinical translation is hampered by exosomal heterogeneity, difficulties in standardization, and suboptimal delivery efficiency and long-term efficacy. Future progress will require the integration of nanotechnology and gene editing to enhance therapeutic functionality, ultimately positioning MSC-Exos as precision biologics for DED.

Indexed as

clinical translationdry eye diseaseinflammationmesenchymal stem cell-derived exosome

Identifiers

PMID42719581
PMCPMC13555284

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.