Evidence map›Paper›PMID 42720683›Full record

ArticleFunction (Oxford, England)2026

Positive allosteric modulator of SERCA pump NDC-1171 attenuates cardiac functional decline in mouse model of Duchenne muscular dystrophy.

Niharika Narra, Alyssa M Richards, Conner C Earl, Abigail D Cox, Russell Dahl, Wendy A Koss, Craig J Goergen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Function (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Niharika NarraWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States.
Alyssa M RichardsWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States.
Conner C EarlWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States.
Abigail D CoxDepartment of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, United States.
Russell DahlNeurodon Corporation, Crown Point, Indiana, United States.
Wendy A KossAnimal Behavior Core, Purdue University, West Lafayette, Indiana, United States.
Craig J GoergenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States.ORCID 0000-0001-8883-7953

Funding

Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug TrialsR01HL167969 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Craig J. Goergen, Kan N Hor · 2024 to 2026
$2.3M
NHLBI NIH HHS R01 HL167969
6 · The paper itself

Abstract

Progressive cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Dysregulation of calcium handling has been implicated in cardiomyopathy progression in DMD. Here we describe a therapeutic approach to improve calcium homeostasis in a mouse model of DMD using the novel therapeutic NDC-1171, which is a positive allosteric modulator of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump. We synthesized NDC-1171 and treated 4-wk-old D2.

Indexed as

CardiomyopathiesMuscular Dystrophy, DuchenneSarcoplasmic Reticulum Calcium-Transporting ATPasesAllosteric RegulationAnimalsCalciumDisease Models, AnimalMaleMiceMice, Inbred DBAMice, Inbred mdxMuscle, SkeletalVentricular Function, LeftCalciumSarcoplasmic Reticulum Calcium-Transporting ATPasescardiac functionD2.mdx mouse modelDuchenne muscular dystrophypharmacokineticsSERCA activation

Identifiers

PMID42720683
PMCPMC13633054

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.