Evidence map›Paper›PMID 42720847›Full record

ArticleGeroScience2026

p16

Hyman B Muss, Canlan Sun, Yuan Chun Ding, Jingran Ji, Thomas A White, Kirsten Nyrop, Nathan K LeBrasseur, Susan L Neuhausen, Natalia Mitin, Mina S Sedrak

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hyman B MussSchool of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-2862-9970
Canlan SunDepartment of Supportive Care Medicine, City of Hope, Duarte, CA, USA.
Yuan Chun DingDepartment of Population Sciences, City of Hope, Duarte, CA, USA.
Jingran JiDepartment of Medicine, University of California Los Angeles, 650 Charles Young Drive South, Los Angeles, CA, USA.
Thomas A WhiteRobert and Arlene Kogod Center On Aging; Department of Physiology, and Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Kirsten NyropSchool of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nathan K LeBrasseurRobert and Arlene Kogod Center On Aging; Department of Physiology, and Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Susan L NeuhausenDepartment of Population Sciences, City of Hope, Duarte, CA, USA.
Natalia MitinSapere Bio, Research Triangle Park, NC, USA.
Mina S SedrakDepartment of Medicine, University of California Los Angeles, 650 Charles Young Drive South, Los Angeles, CA, USA. msedrak@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-8379-391X

Funding

Targeting Senescence to Mitigate Chemotherapy-induced Functional DeclineR01CA280088 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mina S Sedrak · 2023 to 2026
$2.7M
Biomarkers of Molecular Age to Predict the Toxicity of Cancer ChemotherapyR01CA203023 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MUSS, HYMAN · 2016 to 2020
$2.5M
Targeting Senescence to Improve Frailty in Older Cancer SurvivorsK76AG074918 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEDRAK, MINA S · 2022 to 2024
$729k
Using Senolytics to Improve Physical Function in Older Breast Cancer SurvivorsR21CA277660 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEDRAK, MINA S · 2023 to 2024
$422k
Enhancing Skeletal Muscle Recovery and Mitochondrial Function in Older Cancer SurvivorsR01AR087145 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mina S Sedrak, Jonathan Wanagat · 2026 to 2026
$402k
Mitigating Physical Function Decline in Older Adults with Gastroesophageal CancerR03AG095803 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JI, JINGRAN · 2025 to 2025
$394k
NCI NIH HHS R01 CA203023NCI NIH HHS R01CA280088NCI NIH HHS R21CA277660NIA NIH HHS K76AG074918NIA NIH HHS R01 AG55529NIA NIH HHS R03 AG095803NIA NIH HHS R56 AG60907NIH R01AR087145
6 · The paper itself

Abstract

Candidate biomarkers of biologic aging include p16

Indexed as

Biomarkers of agingBreast cancerCellular senescenceChemotherapyDNA methylationEpigenetic clocksP16INK4a

Identifiers

PMID42720847

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.