ArticleChirality2026
Application of threo-2-amino-1,2-diphenylethanol as a Resolving Agent for Racemic Carboxylic Acids via Diastereomeric Salt Formation.
Article in Chirality, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
The ability of threo-2-amino-1,2-diphenylethanol (1t) as a resolving agent for the enantioseparation of carboxylic acids via diastereomeric salt formation was investigated. Although (-)-1t was not applicable to the enantioseparation of racemic 2-arylalkanoic acids and mandelic acid, enantiomers of tropic acid and 2-halomandelic acids were efficiently separated by salt formation with (-)-1t. This resolving ability was complementary to that of the corresponding erythro-isomer (1e). The hydrogen-bonding patterns and molecular packing mode of the less-soluble diastereomeric salts of (-)-1t were revealed based on the crystallographic analysis.
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