Evidence map›Paper›PMID 42722447›Full record

ArticleVeterinary medicine and science2026

Forensic LC-MS/MS Monitoring of Anticoagulant Rodenticide Poisoning in Cats Over a Half-Decade.

HyunYoung Chae, Jae-Won Byun, So-Jeong Yim, Bok-Kyung Ku, Tae-Wan Kim, JeongWoo Kang

Abstract read
In one paragraph

Article in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

HyunYoung ChaeAnimal Disease Diagnosis Division, Animal and Plant Quarantine Agency (APQA), Ministry of Agriculture, Food and Rural Affairs, Gimcheon-si, Republic of Korea.ORCID https://orcid.org/0000-0001-7295-5250
Jae-Won ByunAnimal Disease Diagnosis Division, Animal and Plant Quarantine Agency (APQA), Ministry of Agriculture, Food and Rural Affairs, Gimcheon-si, Republic of Korea.
So-Jeong YimAnimal Disease Diagnosis Division, Animal and Plant Quarantine Agency (APQA), Ministry of Agriculture, Food and Rural Affairs, Gimcheon-si, Republic of Korea.
Bok-Kyung KuAnimal Disease Diagnosis Division, Animal and Plant Quarantine Agency (APQA), Ministry of Agriculture, Food and Rural Affairs, Gimcheon-si, Republic of Korea.
Tae-Wan KimLaboratory of Veterinary Physiology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
JeongWoo KangAnimal Disease Diagnosis Division, Animal and Plant Quarantine Agency (APQA), Ministry of Agriculture, Food and Rural Affairs, Gimcheon-si, Republic of Korea.ORCID https://orcid.org/0000-0002-2097-6137

Funding

Korean Animal and Plant Quarantine Agency B-1543069-2025-26-01
6 · The paper itself

Abstract

backgroundAnticoagulant rodenticides (ARs) are important toxicants in veterinary forensic investigations involving suspected poisoning in cats.

objectivesThis study aimed to develop and validate a standardized LC-MS/MS-QTRAP method for the simultaneous identification and quantification of eight ARs in gastric matrices from cats and to assess its applicability to veterinary forensic toxicology.

methodsAutomated sample preparation was implemented to reduce inter-analyst variability. Dual confirmation using multiple reaction monitoring (MRM) and enhanced product ion (EPI) spectra was applied to improve identification reliability and minimize false-positive results caused by structurally related compounds. The method was applied to 747 cat forensic toxicology cases submitted between January 2020 and August 2025, in which gastric tissue or gastric contents were available for analysis.

resultsARs were detected in 2.5% of cases (19/747). Coumatetralyl was the most frequently detected AR, followed by flocoumafen and bromadiolone. Flocoumafen was detected despite not being an officially registered active ingredient in Korea, highlighting the need for broad multi-analyte screening.

conclusionsThe standardized LC-MS/MS-QTRAP method enabled reliable detection and quantification of ARs in gastric matrices from cats. This approach provides useful forensic evidence of recent AR exposure in suspected poisoning cases and may support improved toxicovigilance for registered and unregistered rodenticides.

Indexed as

AnticoagulantsCat DiseasesForensic ToxicologyLiquid Chromatography-Mass SpectrometryRodenticidesTandem Mass SpectrometryAnimalsCatsChromatography, LiquidAnticoagulantsRodenticidescoumatetralylgastric contentsQTRAPQuEChERStoxicovigilance

Identifiers

PMID42722447
PMCPMC13561683

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.