Evidence map›Paper›PMID 42722639›Full record

ArticleNature communications2026

AAT/SERPINA1 Pi*Z variant linked to gestational length and preterm birth prevention via AAT in mice.

E Koivulehto, A Pasanen, A M Haapalainen, H Tiensuu, M Rämet, M Hallman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E KoivulehtoResearch Unit of Clinical Medicine, University of Oulu, Oulu, Finland. emma.koivulehto@oulu.fi.ORCID http://orcid.org/0009-0009-5526-4250
A PasanenResearch Unit of Clinical Medicine, University of Oulu, Oulu, Finland.ORCID http://orcid.org/0000-0001-7460-5086
A M HaapalainenResearch Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
H TiensuuResearch Unit of Clinical Medicine, University of Oulu, Oulu, Finland.ORCID http://orcid.org/0000-0002-9384-8435
M Rämet *Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.
M Hallman *Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

About 10% of pregnancies end prematurely before 37 weeks, without effective prevention therapies. Previously, we identified rare damaging variants in SERPINA1 encoding alpha-1-antitrypsin (AAT) in families with recurrent spontaneous preterm births and detected decreased protein and transcript levels of AAT/SERPINA1 from placentas in spontaneous preterm births. Here, we investigate genetic associations between SERPINA1 variants and gestational duration and evaluate AAT supplementation as a therapeutic intervention in a mouse model of preterm birth. SERPINA1 Pi*Z variant (rs28929474-T) is associated with gestational duration (P < 5×10

Indexed as

alpha 1-AntitrypsinPremature BirthAnimalsDisease Models, AnimalFemaleGenotypeGestational AgeHumansMiceMice, TransgenicPlacentaPregnancyalpha 1-AntitrypsinSerpina1a protein, mouseSERPINA1 protein, human

Identifiers

PMID42722639
PMCPMC13562590

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.