Evidence map›Paper›PMID 42723272›Full record

ArticleChemMedChem2026

Novel Steroidal (Thio)barbiturate Hybrids: From Design to Preclinical Assessment in Tumor Therapy.

Alexandra Varges, João Serrano, Paula Arias, Pedro Soeiro, Marla Machava, Inês Figueiredo, Eurico Lima, Gilberto Alves, Adriana Oliveira Santos, Renato Boto and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexandra VargesRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.ORCID https://orcid.org/0000-0001-8726-0726
João SerranoRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.ORCID https://orcid.org/0000-0002-0513-7976
Paula AriasRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.
Pedro SoeiroRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.ORCID https://orcid.org/0000-0001-5357-7020
Marla MachavaRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.
Inês FigueiredoRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.
Eurico LimaRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.ORCID https://orcid.org/0000-0002-9402-8949
Gilberto AlvesRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.ORCID https://orcid.org/0000-0002-4213-0714
Adriana Oliveira SantosRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.ORCID https://orcid.org/0000-0002-1224-9191
Renato BotoRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.ORCID https://orcid.org/0000-0002-7256-2622
Paulo AlmeidaRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.ORCID https://orcid.org/0000-0003-0110-4795
Samuel SilvestreRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Covilhã, Portugal.ORCID https://orcid.org/0000-0003-4297-5108
Mariana MatiasRISE-Health, Department of Medical Sciences, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.ORCID https://orcid.org/0000-0002-7649-7418

Funding

FCT (UID/06397/2025, UID/QUI/UI0616/2019, SFRH/BD/148028/2019, SFRH/BD/147645/2019, 2020.07634.BD) Portuguese NMR Network(Grant Infrastructure Project No.022161)PPBI-Portuguese Platform of BioImaging Project POCI-01-0145-FEDER-022122
6 · The paper itself

Abstract

Cancer remains a public health concern with high rates of incidence and mortality, despite the significant advances achieved in recent decades. Therefore, this study aimed to develop novel hybrid molecules with potential anticancer properties. To this end, a steroid nucleus, specifically pregnenolone or dehydroepiandrosterone (DHEA), was covalently linked to a (thio)barbiturate scaffold. The hybrid molecules showed relevant antiproliferative activity against breast (MCF-7) and prostate (PC-3) cancer cells (IC

Indexed as

Antineoplastic AgentsBarbituratesDrug DesignApoptosisCell Line, TumorCell ProliferationDehydroepiandrosteroneDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructurePregnenoloneSteroid 17-alpha-HydroxylaseStructure-Activity RelationshipAntineoplastic AgentsBarbituratesDehydroepiandrosteronePregnenoloneSteroid 17-alpha-Hydroxylaseantiproliferativebarbiturateshybrid moleculespharmacokineticssteroids

Identifiers

PMID42723272
PMCPMC13562818

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.