Evidence map›Paper›PMID 42723356›Full record

ArticleClinical obesity2026

IMPROVE 2025: The 3rd International Meeting on Pathway-Related Obesity: Vision & Evidence.

Jesús Argente, Erica L T van den Akker, Metin Cetiner, Karine Clément, Elizabeth Forsythe, Alastair Garfield, Peter Kühnen, Gabriel Ángel Martos-Moreno, David Meeker, Hermann L Müller and 8 more

Abstract readConference Proceedings
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jesús ArgenteDepartment of Paediatrics and Paediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Research Institute La Princesa, Madrid, Spain.ORCID 0000-0001-5826-0276
Erica L T van den AkkerDepartment of Paediatric Endocrinology, Erasmus MC Children's Hospital, Rotterdam, the Netherlands.ORCID 0000-0001-5352-9328
Metin CetinerDepartment of Paediatrics II, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0002-0918-9204
Karine ClémentINSERM, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Sorbonne Université, Paris, France.
Elizabeth ForsytheGuy's and St Thomas' Hospitals, Great Ormond Street Hospital, London, UK.
Alastair GarfieldRhythm Pharmaceuticals, Inc., Boston, Massachusetts, USA.
Peter KühnenDepartment of Paediatric Endocrinology and Diabetology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Berlin, Berlin, Germany.
Gabriel Ángel Martos-MorenoDepartment of Paediatrics and Paediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Research Institute La Princesa, Madrid, Spain.ORCID 0000-0001-5524-2646
David MeekerRhythm Pharmaceuticals, Inc., Boston, Massachusetts, USA.
Hermann L MüllerDepartment of Paediatrics and Paediatric Hematology/Oncology, University Children's Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg AöR, Oldenburg, Germany.
Hanneke M van SantenDepartment of Paediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, the Netherlands.ORCID 0000-0002-6773-6931
Julia von SchnurbeinDivision of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, University Medical Centre Ulm, Ulm, Germany.
Bérénice SegrestinDepartment of Endocrinology, Diabetes and Nutrition, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, France.ORCID 0000-0001-7926-0144
Tomohiro TanakaDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.ORCID 0000-0002-6212-4274
Manuel Tena-SempereCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
Martin WabitschDivision of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, University Medical Centre Ulm, Ulm, Germany.ORCID 0000-0001-6795-8430
Stefanie ZornDivision of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, University Medical Centre Ulm, Ulm, Germany.
I Sadaf FarooqiInstitute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.

Funding

Rhythm Pharmaceuticals, Inc.
6 · The paper itself

Abstract

An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway-Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2-4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin-4 receptor (MC4R) pathway and to support peer-to-peer sharing of clinical experience and emerging evidence. The programme comprised four sessions covering hyperphagia, monogenic MC4R pathway diseases, Bardet-Biedl syndrome and acquired hypothalamic obesity. Discussions focused on defining and measuring hyperphagia, updates in genetic diagnostics and natural history, real-world and trial data on targeted therapies and practical multidisciplinary models of care with earlier intervention. Patient and caregiver quality of life remained central throughout. These Proceedings summarise the key updates, discussions and initiatives generated at IMPROVE 2025.

Indexed as

HyperphagiaObesityReceptor, Melanocortin, Type 4Bardet-Biedl SyndromeHumansQuality of LifeMC4R protein, humanReceptor, Melanocortin, Type 4acquired hypothalamic obesityBardet–Biedl syndromehyperphagiaMC4R pathwaymonogenic disease

Identifiers

PMID42723356
PMCPMC13562984

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.