ArticleFrontiers in endocrinology2026
The association between the ZJU index and short-term prognosis in patients with acute ischemic stroke: a cohort study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to evaluate the ZJU index-a composite metabolic indicator integrating fasting plasma glucose, body mass index, ALT/AST ratio, and triglycerides-as a predictor of short-term functional outcomes in patients with Acute Ischemic Stroke (AIS) Given the lack of research on this association, the study sought to provide a novel prognostic tool and enhance understanding of metabolic factors in stroke recovery. Methods: This was a Results: Multivariable logistic regression revealed a significant negative correlation between the ZJU index and short-term prognosis in AIS patients (after full adjustment for confounders, continuous variable OR = 0.975, 95% CI: 0.952-0.998). Using the first quartile (Q1) of the ZJU index as reference, patients in the second to fourth quartiles (Q2-Q4) had significantly lower risks of poor prognosis. Restricted cubic spline analysis further indicated a significant non-linear negative correlation between the two (Overall Conclusion: This study demonstrates that ZJU index is independently associated with short-term functional outcomes in AIS patients, and this association is non-linear. As a composite metabolic indicator, the ZJU index holds potential clinical value for assessing prognosis risk and guiding personalized metabolic management in AIS patients.
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