ReviewFrontiers in cell and developmental biology2026
Dysregulated cholesterol metabolism in genodermatoses: implications for systemic disease and therapeutic strategies.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Cholesterol plays a critical role in maintaining normal physiological functions, and it is particularly important in skin tissue. Dysregulation of cholesterol metabolism can lead to a spectrum of skin disorders, including ichthyosis, porokeratosis, keratosis follicularis spinulosa decalvans and related diseases. While the pathogenesis of certain genodermatoses of keratinization has been clearly linked to abnormal cholesterol metabolism, known genetic mutations account for only a subset of cases, suggesting additional cholesterol-linked modifiers, suggesting a potential involvement of cholesterol-related pathways. This review summarizes recent advances in understanding genodermatoses of keratinization associated with disrupted cholesterol metabolism and discusses their underlying molecular mechanisms. A better understanding of cholesterol dysregulation may facilitate the identification of novel diagnostic biomarkers and therapeutic targets, providing new opportunities for precision management of inherited keratinization disorders.
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