ArticleFrontiers in cell and developmental biology2026
β-Hydroxybutyrate-induced mitochondrial dysfunction and oxidative stress in BMSCs are ameliorated by mitophagy activation.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ketosis is a common metabolic disorder in periparturient dairy cows and is characterized by elevated circulating BHBA concentrations. Although the effects of ketosis on hepatic metabolism have been extensively studied, its impact on skeletal muscle remains poorly understood. This study investigated the effects of BHBA on bovine muscle satellite cells (BMSCs) and the role of mitochondrial quality control in BHBA-induced cellular injury. BHBA treatment significantly inhibited BMSC proliferation, promoted apoptosis, increased intracellular and mitochondrial ROS accumulation, reduced antioxidant enzyme activities, and impaired mitochondrial membrane potential in a dose-dependent manner. BHBA also disrupted mitochondrial ultrastructure, altered the expression of mitochondrial respiratory chain genes, promoted mitochondrial fission, and suppressed mitophagy. Similar effects were observed in C
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