Evidence map›Paper›PMID 42724714›Full record

ArticleBiophysics reports2026

Stem cell-derived exosomes preserve diabetic islet function: a systematic review and meta-analysis of preclinical studies.

Yingling Jiang, Lihua Chen, Haopeng Lin, Tongran Zhang, Xin Liu, Zhihua Dou, Xu Wei, Lizhe Cai, Yan Hu, Huisheng Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yingling JiangGraduate School, Xinjiang Medical University, Urumqi 830054, China.
Lihua ChenState Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A & F University, Hangzhou 311300, China.
Haopeng LinSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, China.
Tongran ZhangShenzhen University Medical School, Shenzhen University, Shenzhen 518055, Guangdong, China.
Xin LiuDepartment of Endocrinology and Metabolism, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Diabetes, Xinjiang Endocrinology Diabetes Institute, Xinjiang Key Laboratory of Cardiovascular Homeostasis and Regeneration Research, Urumqi 830001, China.
Zhihua DouDepartment of Endocrinology and Metabolism, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Diabetes, Xinjiang Endocrinology Diabetes Institute, Xinjiang Key Laboratory of Cardiovascular Homeostasis and Regeneration Research, Urumqi 830001, China.
Xu WeiGuangzhou National Laboratory, Guangzhou 510005, China.
Lizhe CaiSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou 511436, China.
Yan HuDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.
Huisheng LiuDepartment of Endocrinology and Metabolism, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Diabetes, Xinjiang Endocrinology Diabetes Institute, Xinjiang Key Laboratory of Cardiovascular Homeostasis and Regeneration Research, Urumqi 830001, China.
Yanying GuoDepartment of Endocrinology and Metabolism, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Diabetes, Xinjiang Endocrinology Diabetes Institute, Xinjiang Key Laboratory of Cardiovascular Homeostasis and Regeneration Research, Urumqi 830001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes remains an incurable disease, and emerging evidence suggests that exosomes may offer promising therapeutic potential for both diabetes and its complications. However, their specific effects on pancreatic islet function are still under investigation. This meta-analysis aimed to evaluate the efficacy of stem cell-derived exosomes (SC-Exs) in preserving islet function in diabetes. A comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases was conducted from inception to May 1, 2025, to identify studies assessing the impact of SC-Exs on islet function in diabetic models. Data on insulin levels, islet quantity, and inflammatory markers were extracted and analyzed using Stata 14.0 and Review Manager (RevMan) 5 software. Ten eligible studies were included in the meta-analysis. Compared with controls, SC-Exs significantly increased insulin levels (SMD = 10.09, 95% CI: 7.97-12.21,

Indexed as

DiabetesExosomesIslet functionMeta-analysisStem cell

Identifiers

PMID42724714
PMCPMC13559524

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.