Evidence map›Paper›PMID 42725207›Full record

ArticleTransplantation direct2026

Effects of End-ischemic Hypothermic Oxygenated Perfusion on 1-y Graft Function in Kidney Transplantation: A Real-world, Single-center Analysis From the United States.

Justin A Steggerda, Tiffany Lim, Irene K Kim, Tsuyoshi Todo, Edmund Huang, Todd V Brennan, Georgios Voidonikolas, Alice Peng, Reiad Najjar, Jun Shoji and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Justin A SteggerdaDivision of Abdominal Transplantation, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.ORCID https://orcid.org/0000-0001-9320-9871
Tiffany LimDivision of Abdominal Transplantation, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Irene K KimDivision of Abdominal Transplantation, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Tsuyoshi TodoDivision of Abdominal Transplantation, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Edmund HuangComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Todd V BrennanDivision of Abdominal Transplantation, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Georgios VoidonikolasDivision of Abdominal Transplantation, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Alice PengComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Reiad NajjarComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Jun ShojiComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Stanley JordanComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Sindhu ChandranComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Emma CrichtonDivision of Abdominal Transplantation, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Benjamin FerrelProvidence Kidney and Pancreas Transplant, Sacred Heart Hospital, Spokane, WA.
Jose Reyes-PerezLewis Katz School of Medicine, Temple University, Philadelphia, PA.
Manaf AlsudaneyComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Peter S HeegerComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Steven A WiselDivision of Abdominal Transplantation, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypothermic oxygenated perfusion (HOPE) supplies oxygen to kidney allografts for resuscitation before transplantation and may improve graft recovery. This study represents the first U.S.-based comparative analysis evaluating the impact of HOPE on kidney transplant (KT) outcomes. Methods: A retrospective, single-center study of adult, deceased-donor, kidney-only transplants performed between December 1, 2023, and March 31, 2025. Transplants were grouped according to preservation method: HOPE, static cold storage (SCS), or hypothermic machine perfusion (HMP) without oxygen alone. The primary outcome was 12-mo estimated glomerular filtration rate (eGFR). Subgroup analyses were performed, including donation after circulatory death (DCD) and long cold ischemic time (>18 h) KT. A matched cohort analysis was performed for DCD-KT. Kruskal-Wallis rank-sum and pairwise comparisons were used. Results: Among 279 KT, 137 (49.1%) used SCS, 56 (20.1%) HOPE, and 86 (30.8%) HMP. There were few differences in baseline characteristics between groups, including donor age, kidney donor profile index, donor serum creatinine, and recipient age. Preservation time was significantly longer with HOPE (median 27.9 versus SCS 18.3 versus HMP 20.2 h; Conclusions: HOPE preservation is associated with improved long-term graft function compared with HMP while maintaining outcomes compared with SCS despite longer preservation times, with notable benefits in DCD-KT.

Identifiers

PMID42725207
PMCPMC13561228

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.