Evidence map›Paper›PMID 42725574›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

A Novel Reporter Mouse for Astrocyte-Derived Extracellular Vesicles Reveals Enrichment of Cargo at Neuronal Mitochondria.

Xiaojia Ren, Zainuddin Quadri, Zhihui Zhu, Xu Fu, Liping Zhang, Erhard Bieberich

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Xiaojia RenDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0009-0001-7741-133X
Zainuddin QuadriDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Zhihui ZhuDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Xu FuDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Liping ZhangDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Erhard BieberichDepartment of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0001-8490-7395

Funding

Function of ceramide in extracellular vesicle-mediated neurodegenerative diseaseRF1AG078338 · NIA · UNIVERSITY OF KENTUCKY · PI BIEBERICH, ERHARD · 2022 to 2025
$2.6M
Novel experimental models to study the effect of extracellular vesicles on neuronsR21AG078601 · NIA · UNIVERSITY OF KENTUCKY · PI BIEBERICH, ERHARD · 2022 to 2022
$421k
BLRD VA I01 BX007282HHS | National Institutes of Health (NIH) R21AG078601HHS | National Institutes of Health (NIH) RF1AG078338NIA NIH HHS R21 AG078601NIA NIH HHS RF1 AG078338U.S. Department of Veterans Affairs (VA) 1I01BX007282
6 · The paper itself

Abstract

Extracellular vesicles (EVs) mediate intercellular transfer of lipids, proteins, and nucleic acids between cell types. We previously showed that astrocyte-derived EVs modulate neuronal mitochondria in vitro. Whether endogenous astrocytic EVs associate with neuronal mitochondria in vivo remained unknown. To address this, we generated an EV reporter mouse, Aldh1l1-Cre; CD9-tGFP

Indexed as

AstrocytesExtracellular VesiclesMitochondriaNeuronsAldehyde Dehydrogenase 1 FamilyAnimalsBrainCells, CulturedMiceMice, Inbred C57BLMice, TransgenicRetinal DehydrogenaseTetraspanin 29Aldehyde Dehydrogenase 1 FamilyALDH1A1 protein, mouseCd9 protein, mouseRetinal DehydrogenaseTetraspanin 29astrocyteCD9‐turboGFPEV reporter miceextracellular vesicles (EVs)mitochondriatetraspanins

Identifiers

PMID42725574
PMCPMC13563685

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.