ArticlePsychopharmacology2026
Enantiomer-specific modulation of GABA
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
rationalePost-traumatic stress disorder (PTSD) is a debilitating psychiatric condition that can emerge following exposure to severe trauma and is frequently accompanied by comorbid psychiatric symptoms, including psychosis. Hallucinations and delusions associated with PTSD are thought to arise from dysregulated mesolimbic dopamine signaling; however, converging evidence indicates dopamine dysfunction is secondary to hippocampal hyperactivity driven by impaired GABAergic transmission. An emerging pharmacological strategy is the use of positive allosteric modulators (PAMs) of GABA
objectivesWhether this therapeutic potential reflects α-subunit specificity or broader properties of structurally related PAMs remains unclear. We compared three structurally related GABA
methodsUsing an acute inescapable footshock stress model, which reliably produces increased mesolimbic dopamine activity, we performed in vivo extracellular electrophysiology to record dopamine neuron activity in the ventral tegmental area (VTA) after intra-hippocampal administration of GABA
resultsMP-III-022, a selective α5-GABA
conclusionsThese findings indicate that stereochemical and subunit-selective modulation of GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.