Evidence map›Paper›PMID 42726344›Full record

ArticleMetabolic brain disease2026

Differential metabolic and cellular brain regional susceptibility in adult rats with chronic liver disease.

Dunja Simicic, Katarzyna Pierzchala, Olivier Braissant, Dario Sessa, Valérie McLin, Cristina Cudalbu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolic brain disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dunja Simicic *CIBM Center for Biomedical Imaging, Lausanne, Switzerland. dsimici1@jh.edu.ORCID http://orcid.org/0000-0002-6600-2696
Katarzyna Pierzchala *CIBM Center for Biomedical Imaging, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-6550-8364
Olivier BraissantService of Clinical Chemistry, University of Lausanne and Lausanne University Hospital, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0659-755X
Dario SessaSwiss Pediatric Liver Center, Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland.
Valérie McLinSwiss Pediatric Liver Center, Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-0711-687X
Cristina CudalbuCIBM Center for Biomedical Imaging, Lausanne, Switzerland. cristina.cudalbu@epfl.ch.ORCID http://orcid.org/0000-0003-4582-2465

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with type C hepatic encephalopathy (HE) present diverse symptoms, indicating disease-associated effects in multiple brain regions. While identifying the distinct metabolic and cellular changes in these regions could help explain the clinical variability of HE, this remains challenging. By leveraging the non-invasive capabilities of in-vivo

Indexed as

BrainHepatic EncephalopathyLiver DiseasesAnimalsDisease Models, AnimalGlutamineMagnetic Resonance SpectroscopyMaleRatsRats, Sprague-DawleyGlutamineBile duct ligationCentral nervous systemGlutamineProton magnetic resonance spectroscopyType C hepatic encephalopathy

Identifiers

PMID42726344
PMCPMC13569521

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.