ArticleScience advances2026
RNA-independent cis-autoregulatory circuits within bidirectional gene pairs control metabolism.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Many genes share promoters with another gene on the opposite DNA strand, forming bidirectional pairs. During metabolic transitions, most pairs are coordinately regulated in the liver, in part through chromatin topology. In pairs composed of a long noncoding RNA (lncRNA) and a protein-coding gene (PCG), lncRNA transcription cis-activates PCG transcription by establishing an active chromatin environment at the promoter-proximal enhancer of PCG. Reciprocally, PCG transcription cis-inhibits lncRNA transcription, forming internal cis-autoregulatory circuits. Both directions of regulation are independent of the RNA products but dependent on the transcription process itself. Similar promoter-proximal enhancer signatures and cis-autoregulatory circuits are present in many lncRNA/PCG and PCG/PCG pairs, underscoring the generalizability of these circuits. Using the conserved lncRNA/PCG pair
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