Evidence map›Paper›PMID 42728391›Full record

ReviewNature reviews. Neuroscience2026

Defining the electrical synapse.

Alberto E Pereda, Adam C Miller

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alberto E PeredaDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY, USA. alberto.pereda@einsteinmed.edu.
Adam C MillerInstitute of Neuroscience, University of Oregon, Eugene, OR, USA.ORCID http://orcid.org/0000-0001-7519-3677

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
NICHD NIH HHS P50 HD105352
6 · The paper itself

Abstract

Electrical and chemical synapses together shape neural circuits critically required for the processing of information by the nervous system. Owing to the relative simplicity of the mechanism of action mediating electrical coupling between neurons, electrical transmission is generally perceived as static and results solely from the function of intercellular channels at structures known as 'gap junctions'. However, electrical synapses are dynamic structures that exhibit changes in their synaptic strength, indicating a need for a deeper understanding of the determinants regulating their structure and plasticity. Mounting evidence indicates that, beyond the intercellular channels, electrical transmission is supported by sophisticated synaptic structures with an unanticipated complexity in their molecular organization, requiring a new, broader definition of electrical synapses.

Identifiers

PMID42728391

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.