Evidence map›Paper›PMID 42728853›Full record

ArticlePharmaceutical biology2026

A design of experiments approach to production of medicinal bioactives in

Ryland T Giebelhaus, Paula N Brown, Mariam Ali, Amy M Dodds, Lauren A E Erland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryland T GiebelhausDepartment of Chemistry, University of Victoria, Victoria, British Columbia, Canada.
Paula N BrownCentre for Applied Research and Innovation, BC Institute of Technology, Burnaby, British Columbia, Canada.
Mariam AliDepartment of Chemistry, University of Victoria, Victoria, British Columbia, Canada.
Amy M DoddsDepartment of Chemistry, University of Victoria, Victoria, British Columbia, Canada.
Lauren A E ErlandAgriculture, University of the Fraser Valley, Stó:lō Temexw, Abbotsford, British Columbia, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

context

objectiveThis study aimed to optimize MATERIALS AND

methodsA DOE approach was used to minimize the number of treatments necessary to optimize

resultsWe found no significant difference in the quantified levels of mitragynine, melatonin, and some related metabolites, between DISCUSSION AND

conclusionsThe presence of similar specialized metabolite profiles in greenhouse and

Indexed as

MitragynaPlant ExtractsResearch DesignSecologanin Tryptamine AlkaloidsChromatography, High Pressure LiquidMelatoninMetabolomicsPlant RootsPlant ShootsPlants, MedicinalTandem Mass SpectrometryMelatoninmitragyninePlant ExtractsSecologanin Tryptamine AlkaloidsDesign of experimentskratommelatoninMitragyna speciosamitragynine

Identifiers

PMID42728853
PMCPMC13573522

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.