Evidence map›Paper›PMID 42729175›Full record

ArticleFrontiers in public health2026

Lineage structure and penicillin-binding protein variability in clinical

Chenglin Miao, Ziyi Yan, Li Liu, Xin Huang, Yingying Li, Linghan Kuang, Xingxin Liu, Jiaji Ling, Jingjing Luo, Huilian Chen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chenglin Miao *Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Ziyi Yan *Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Li LiuDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Xin HuangDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Yingying LiDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Linghan KuangDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Xingxin LiuDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Jiaji LingDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Jingjing LuoDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Huilian ChenDepartment of Laboratory Medicine, West China Second University Hospital (Tianfu), Sichuan University (Sichuan Provincial Children's Hospital), Meishan, China.
Xiaocui HuangDepartment of Laboratory Medicine, Chengdu Jinjiang District Maternal and Child Healthcare Hospital, Chengdu, China.
Xinghua ZhuDepartment of Laboratory Medicine, The First People's Hospital of Longquanyi District, Chengdu, China.
Yali CuiDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Yi XieDepartment of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University (Sichuan Clinical Research Center for Laboratory Medicine), Chengdu, China.
Yongmei JiangDepartment of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Reduced susceptibility to penicillin in Methods: We performed whole-genome sequencing of 204 clinical Results: The isolates showed a high burden of resistance to non-β-lactam antibiotics (erythromycin, 98.5%; tetracycline, 82.8%; trimethoprim-sulfamethoxazole, 64.7%), while fluoroquinolone susceptibility was largely preserved (≥97%), and vancomycin/linezolid resistance was not detected. Twenty-seven serotypes were identified, among which 19F (23.5%) and 19A (14.2%) were dominant, and the estimated PCV13 coverage was 69.6%. GPSC1 was the dominant lineage (36.8%), and the lineage composition among our isolates differed markedly from those in the PubMLST-USA and PubMLST-Thailand subsets. Virulence and resistance gene carriage differed markedly between GPSC1 and non-GPSC1 isolates, with enrichment of pilus operons, Conclusion: Clinical

Indexed as

Anti-Bacterial AgentsPenicillin-Binding ProteinsPenicillin ResistancePenicillinsPneumococcal InfectionsStreptococcus pneumoniaeChinaHumansMicrobial Sensitivity TestsPhylogenyWhole Genome SequencingAnti-Bacterial AgentsPenicillin-Binding ProteinsPenicillinsantimicrobial resistanceChinaglobal pneumococcal sequence clusterGPSCPBPspenicillinpenicillin-binding proteinsStreptococcus pneumoniae

Identifiers

PMID42729175
PMCPMC13561796

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.