ArticleFrontiers in nutrition2026
Phenotype-specific 25-hydroxyvitamin D and fat-soluble vitamin profiles in girls with pediatric endocrine disorders: a large cross-sectional study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To characterize serum vitamin A, total 25-hydroxyvitamin D [25(OH)D] and vitamin E across common pediatric endocrine disorders in girls and to test whether the profiles are phenotype-specific. Methods: In this single-center retrospective cross-sectional study, serum vitamin A, total 25(OH)D, and vitamin E were simultaneously measured by high-performance liquid chromatography in 4,111 girls aged 3-13 years, including healthy controls ( Results: Each phenotype demonstrated a distinct fat-soluble vitamin profile. Obesity was characterized by higher vitamin A (adjusted Cohen's Conclusion: In girls, common pediatric endocrine disorders carry distinct, phenotype-specific fat-soluble vitamin profiles, with CPP and short stature diverging in opposite directions for vitamin D. Effect sizes were modest, and the short-stature elevation may substantially reflect unmeasured cholecalciferol supplementation; these group-level patterns therefore warrant cautious, biomarker-oriented interpretation.
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