Evidence map›Paper›PMID 42729493›Full record

ArticleMaterials today. Bio2026

Spatiotemporal delivery of endplate-targeted single-atom cerium nanozyme for immune-vascular crosstalk modulation and sclerosis attenuation.

Yonggang Fan, Jianwei Li, Mengdie Jin, Lu Li, Yuheng Zhang, Yu Dong, Jie Guo, Xin Liu, Le Peng, Qiong Tang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yonggang FanDepartment of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Nankai University, Tianjin, 300121, China.
Jianwei LiDepartment of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Nankai University, Tianjin, 300121, China.
Mengdie JinTianjin Key Lab for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, School of Materials Science and Engineering, National Institute for Advanced Materials, Nankai University, Tianjin, 300350, China.
Lu LiCore Facility of Research Center of Basic Medical Science, Tianjin Medical University, Tianjin, 300072, China.
Yuheng ZhangState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.
Yu DongDepartment of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Nankai University, Tianjin, 300121, China.
Jie GuoTianjin Medical University, Tianjin, 300072, China.
Xin LiuTianjin Medical University, Tianjin, 300072, China.
Le PengTianjin Key Lab for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, School of Materials Science and Engineering, National Institute for Advanced Materials, Nankai University, Tianjin, 300350, China.
Qiong TangDepartment of Respiratory, Tianjin Union Medical Center, Tianjin, 300121, China.
Xinyun ZhaiTianjin Key Lab for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, School of Materials Science and Engineering, National Institute for Advanced Materials, Nankai University, Tianjin, 300350, China.
Tianwei SunDepartment of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Nankai University, Tianjin, 300121, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cartilage endplate (CEP) sclerosis is a critical pathological hallmark of intervertebral disc degeneration (IVDD) and a major contributor to low back pain, with reactive oxygen species (ROS) emerging as key upstream drivers of this process. Here, we report the design of a CEP-targeted cerium single-atom nanozyme (CAP@Ce SAs) that integrates ROS-scavenging capacity with tissue-specific targeting. CAP@Ce SAs exhibited robust superoxide dismutase- and catalase-like activities as well as hydroxyl radical elimination, while selective CEP enrichment was achieved via conjugation of the CEP-binding CAP peptide. In a lumbar spinal instability mouse model, CAP@Ce SAs effectively alleviated CEP degeneration and sclerosis, suppressed macrophage infiltration, and inhibited aberrant Type-H vessel angiogenesis. In vitro, CAP@Ce SAs protected chondrocytes from oxidative stress, and bulk RNA-seq combined with mechanistic validation demonstrated that the therapeutic effects are mediated by modulation of the ROS-Hippo-CCL5 axis. To our knowledge, this is the first CEP-targeted nanozyme that couples single-atom cerium catalysis with peptide-guided delivery, providing a precision strategy to remodel the immune-vascular microenvironment of CEP. These findings establish CAP@Ce SAs as a promising biomaterial platform for endplate-centered intervention in degenerative disc disease.

Indexed as

Cartilage endplateImmune-vascular crosstalkNanozymeOxidative stressSingle-atom cerium

Identifiers

PMID42729493
PMCPMC13562675

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.