Multi-biomimetic poly(amino acid)-based Janus membrane integrating barrier and osteoinductive functions for cranial bone regeneration.

Youming Xu, Yuxin Zhang, Jiyuan Chen, Zihan Zhuang, Chen Zhang, Kaixuan Ren, Dong Chen, Jingbo Yin

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Youming XuDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, PR China.

Yuxin ZhangDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, 200001, PR China.

Jiyuan ChenDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, PR China.

Zihan ZhuangDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, PR China.

Chen ZhangDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, 200001, PR China.

Kaixuan RenDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, PR China.

Dong ChenDepartment of Endodontics, Shanghai Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, 200001, PR China.

Jingbo YinDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guided bone regeneration (GBR) membranes play a critical role in repairing bone defects, yet conventional collagen-based membranes suffer from immunogenicity, insufficient mechanical strength, and lack of osteoinductivity. Herein, a multi-biomimetic poly(γ-benzyl-L-glutamate) (PBLG)-based Janus membrane (PP-S/MH-P) is constructed that integrates a robust barrier function with potent osteoinductive capacity. The membrane is fabricated with a Janus architecture: PP-S side consists of a dense poly(γ-benzyl-L-glutamate) (PBLG) barrier layer, physically blended with PEGDA and surface-grafted with zwitterionic poly(sulfobetaine methacrylate) (PSBMA) brushes, the opposite MH-P side comprises Mg-doped hydroxyapatite surface-grafted with PBLG, forming a bone-mimetic nanofibrous network. The membrane exhibits robust mechanical properties (tensile strength: 5.42 MPa; elastic modulus: 141.72 MPa), favorable wet tissue conformability, and enzymatic degradation. The PP-S side effectively resists bacterial (

Indexed as

Barrier functionBone regenerationGuided bone regenerationJanus membraneOsteoinductive activitypoly(amino acid)

Identifiers

PMID42729692

DOI10.1016/j.mtbio.2026.103616

PMCPMC13563575

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.