Evidence map›Paper›PMID 42729987›Full record

ReviewHealth affairs scholar2026

Financing and health system capacity for precision medicine in Asia: a six country landscape analysis.

Adena Li Tyin Peh, Yot Teerawattananon, Jeanette Xue Yan Yuen, Nordin Charafi, Dicky Levenus Tahapary, Jiahua Leng, Alec Morton, Sheyu Li, Woo Jin Kim, Bin Alwi Zilfalil and 8 more

Abstract readReview
In one paragraph

Review in Health affairs scholar, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Adena Li Tyin PehSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.ORCID https://orcid.org/0009-0009-9704-6593
Yot TeerawattananonHealth Intervention and Technology Assessment Program (HITAP), Department of Health, Ministry of Public Health, Nonthaburi 11000, Thailand.ORCID https://orcid.org/0000-0003-2217-2930
Jeanette Xue Yan YuenDepartment of Cancer Genetics Service, National Cancer Centre Singapore, Singapore 168583, Singapore.ORCID https://orcid.org/0000-0003-0046-3518
Nordin CharafiIllumina Pte Ltd, Singapore 138667, Singapore.ORCID https://orcid.org/0009-0009-8822-7069
Dicky Levenus TahaparyMetabolic, Cardiovascular, and Aging Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia.ORCID https://orcid.org/0000-0002-4048-5159
Jiahua LengKey Laboratory of Carcinogenesis and Translational Research (MOE/Beijing), Gastrointestinal Center Unit III, Peking University Cancer Hospital & Institute, Beijing 100142, China.ORCID https://orcid.org/0000-0003-4613-658X
Alec MortonSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.ORCID https://orcid.org/0000-0003-3803-8517
Sheyu LiDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0003-0060-0287
Woo Jin KimDepartment of Internal Medicine, Kangwon National University Hospital, Kangwon National University, Chuncheon 24289, South Korea.ORCID https://orcid.org/0000-0003-2927-370X
Bin Alwi ZilfalilHuman Genome Center, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Hidayati Husainy HasbullahHuman Genome Center, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.ORCID https://orcid.org/0009-0006-7360-2055
Nusara SatproedpraiEastern Economic Corridor Office of Thailand (EECO), Bangkok 10500, Thailand.ORCID https://orcid.org/0000-0001-8754-231X
Shao-Tzu LiDepartment of Cancer Genetics Service, National Cancer Centre Singapore, Singapore 168583, Singapore.ORCID https://orcid.org/0009-0008-4508-1066
Joanne Yuen Yie NgeowDepartment of Cancer Genetics Service, National Cancer Centre Singapore, Singapore 168583, Singapore.ORCID https://orcid.org/0000-0003-1558-3627
Yah Ru JuangSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.ORCID https://orcid.org/0009-0000-4895-651X
Yue ZhangSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.ORCID https://orcid.org/0009-0000-5690-6117
Minji HongSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.ORCID https://orcid.org/0009-0009-7506-3165
Wenjia ChenSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.ORCID https://orcid.org/0000-0001-8201-7145

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Precision medicine (PM) adoption is accelerating across Asia, but implementation remains uneven due to differences in financing, infrastructure, governance, and health-system readiness. Objectives: To examine how six Asian countries (Singapore, South Korea, China, Malaysia, Thailand, and Indonesia) adopt, finance, and integrate PM technologies, and identify common implementation patterns and challenges. Methods: A landscape review of peer-reviewed literature, government publications, and HTA reports (2010-2026) was conducted, supplemented by stakeholder consultations. PM applications were grouped into public health screening (hereditary breast and ovarian cancer [HBOC] and familial hypercholesterolemia [FH] cascade testing), next-generation sequencing (NGS) applications (rare diseases, oncology, pharmacogenomics), and AI-enabled PM. Evidence was synthesized across access, awareness, reimbursement, and implementation. Results: Public health genomic screening demonstrated the highest implementation readiness, followed by precision oncology, while rare disease diagnostics remained infrastructure-dependent and pharmacogenomics and AI-enabled PM platforms were at earlier stages. Four readiness profiles emerged: highly aligned systems; reimbursement-constrained systems with strong governance and infrastructure; systems strengthening governance, public financing and infrastructure; and strategy-led systems expanding implementation through pilot programs and referral centers. Conclusions: PM implementation across Asia remains heterogeneous. The identified readiness profiles highlight governance, financing, and infrastructure priorities for sustainable and equitable PM diffusion.

Indexed as

Asiagenomic medicinehealth technology assessmentimplementation sciencepharmacogenomicsprecision medicinereimbursement policy

Identifiers

PMID42729987
PMCPMC13564229

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.