ArticleEuropean journal of anaesthesiology and intensive care2026
Hepatic clamping and postoperative hyperglycaemia: A retrospective cohort study in liver surgery.
Article in European journal of anaesthesiology and intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe Pringle manoeuvre, which involves intermittent clamping of the hepatic pedicle, is a common surgical strategy employed to reduce blood loss during liver resection. Although its impact on intra-operative glucose levels has been documented, its contribution to postoperative hyperglycaemia remained an untested hypothesis.
objectivesThe primary aim of this study was to determine whether hepatic vascular clamping was associated with increased postoperative hyperglycaemia within 24 h after liver surgery. Secondary aims included examining the association between postoperative hyperglycaemia and infectious complications and length of hospital stay.
designA retrospective observational cohort study.
settingSingle tertiary university hospital. The study period extended from January 2020 to June 2022. PATIENTS: The study sample comprised 163 adult patients who underwent elective liver resection. Patients were grouped according to the intra-operative use of the Pringle manoeuvre: 107 patients underwent clamping (Pringle group), while 56 patients did not undergo clamping (No-Pringle group). No patients were excluded, and data were complete for all individuals included.
main outcome measuresThe primary outcome was the occurrence of postoperative hyperglycaemia, defined as blood glucose at least 10.0 mmol l
resultsPostoperative hyperglycaemia occurred in 55.1% of patients in the Pringle group compared to 23.2% in the No-Pringle group (
conclusionsThe Pringle manoeuvre was associated with increased postoperative hyperglycaemia within 24 h after liver surgery. These findings underscore the necessity for proactive intra-operative and postoperative glucose control strategies as an integral component of peri-operative management in hepatic surgery.
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