Evidence map›Paper›PMID 42730385›Full record

ArticleFibrosis (Hong Kong, China)2026

Comparison of the Transcriptomic Signatures of Skin and Lung Fibroblasts from Patients with Systemic Sclerosis.

Samantha E Kotz, Ludivine Renaud, Carol A Feghali-Bostwick

Abstract read
In one paragraph

Article in Fibrosis (Hong Kong, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samantha E KotzDepartment of Medicine, Division of Rheumatology and Immunology, MUSC, Charleston, SC 29425, USA.
Ludivine RenaudDepartment of Medicine, Division of Rheumatology and Immunology, MUSC, Charleston, SC 29425, USA.
Carol A Feghali-BostwickDepartment of Medicine, Division of Rheumatology and Immunology, MUSC, Charleston, SC 29425, USA.

Funding

Scleroderma Twin Study and analysis of Estrogen in patients with dcSScK24AR060297 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FEGHALI-BOSTWICK, CAROL A. · 2013 to 2025
$1.4M
Epigenetic Regulation of KLF4 in SSc-associated lung fibrosisK01AR083019 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Ludivine Renaud · 2024 to 2026
$360k
NIAMS NIH HHS K01 AR083019NIAMS NIH HHS K24 AR060297
6 · The paper itself

Abstract

Systemic Sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis in connective tissues. Fibroblasts are the effector cells of fibrosis since they contribute to the production of collagen and other extracellular matrix components. The goal of this study is to compare the transcriptomic profiles of primary human SSc skin and SSc lung fibroblasts. First, we conducted a meta-analysis of differentially expressed (DE) genes from two previously published differential analyses (SSc

Indexed as

FibroblastsLungMeta-analysisRNA sequencingSclerodermaSkinSystemic sclerosisTranscriptome

Identifiers

PMID42730385
PMCPMC13568683

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.