Evidence map›Paper›PMID 42730705›Full record

ArticlePain research & management2026

Exosomal Adiponectin Plays a Role in Electroacupuncture Analgesia by Activating the Adiponectin Receptor 1 to Inhibit Pain-Related Pathways in Mice Brain.

Hsien-Yin Liao, Younbyoung Chae, Chien-Yi Ho, I-Han Hsiao, Ming-Chia Lin, Yu-Ching Wang, Yi-Wen Lin

Abstract read
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In one paragraph

Article in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hsien-Yin LiaoCollege of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 404328, Taiwan, cmu.edu.tw.ORCID https://orcid.org/0000-0002-3853-8450
Younbyoung ChaeAcupuncture and Meridian Science Research Center, Kyung Hee University, Seoul 02453, South Korea, khu.ac.kr.ORCID https://orcid.org/0000-0001-6787-2215
Chien-Yi HoDepartment of Biomedical Imaging and Radiological Science, China Medical University, Taichung 404328, Taiwan, cmu.edu.tw.ORCID https://orcid.org/0000-0002-5574-6446
I-Han HsiaoSchool of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan, cmu.edu.tw.ORCID https://orcid.org/0000-0002-6245-9023
Ming-Chia LinDepartment of Nuclear Medicine, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan, isu.edu.tw.ORCID https://orcid.org/0000-0002-2398-8715
Yu-Ching WangDepartment of Family Medicine, China Medical University Hsinchu Hospital, Hsinchu 302233, Taiwan, cmu.edu.tw.ORCID https://orcid.org/0009-0003-3414-001X
Yi-Wen LinGraduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 404328, Taiwan, cmu.edu.tw.ORCID https://orcid.org/0000-0001-7204-8837

Funding

China Medical University Hsinchu Hospital CMUHCH-CMU-115-008Ministry of EducationNational Science and Technology Council NSTC 114-2314-B-039-031National Science and Technology Council NSTC 114-2314-B-039-087
6 · The paper itself

Abstract

objectiveFibromyalgia (FM) is a difficult-to-cure disease, and finding effective pain management methods is crucial for providing clinicians and healthcare. Adiponectin (ADP) is considered a peripheral metabolic hormone, but its role in the central nervous system remains unknown, especially in pain management. Electroacupuncture (EA) has long been scientifically proven as an effective therapy for pain relief.

methodsWe aimed to investigate the molecular mechanisms in the thalamus, somatosensory cortex, anterior cingulate cortex, and medial prefrontal cortex during intermittent cold stress (ICS)-induced FM in mice, and the inhibitory effects of 2-Hz EA stimulation or intracerebral ventricle (ICV) injection of ADP on this FM model.

resultsResults showed that the FM group significantly produced mechanical and thermal hyperalgesia (

conclusionOur results confirm that 2-Hz EA can treat FM pain, and its mechanism of action is through the activation of AdipoR1 and its downstream related molecular pathways.

Indexed as

AdiponectinBrainElectroacupunctureExosomesPainReceptors, AdiponectinAnimalsDisease Models, AnimalHyperalgesiaMaleMiceMice, Inbred C57BLS100 Calcium Binding Protein beta SubunitSignal TransductionAdiponectinadiponectin receptor 1, mouseReceptors, AdiponectinS100 Calcium Binding Protein beta SubunitadiponectinelectroacupunctureexosomefibromyalgiapPI3KSIRT1

Identifiers

PMID42730705
PMCPMC13570600

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.