Evidence map›Paper›PMID 42733033›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Associations between serum estradiol and estrone and Alzheimer's disease biomarkers: An analysis in female participants from the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study (EPAD LCS).

Juehyun Shin, Graciela Muniz-Terrera, Craig W Ritchie, Jean Manson, Susan Plachecki, Clemens Kirschbaum, Sarah Gregory

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juehyun ShinHeritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.ORCID https://orcid.org/0000-0002-3374-794X
Graciela Muniz-TerreraHeritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA.
Craig W RitchieScottish Brain Sciences, Edinburgh, UK.
Jean MansonUniversity of Edinburgh, Edinburgh, UK.
Susan PlacheckiDresden LABservice GmbH, Dresden, Germany.
Clemens KirschbaumDresden LABservice GmbH, Dresden, Germany.
Sarah GregoryScottish Brain Sciences, Edinburgh, UK.

Funding

Alzheimer's Association SAGA23-1140910
6 · The paper itself

Abstract

introductionPostmenopausal estrogen decline may contribute to Alzheimer's disease (AD), but evidence linking circulating estrogens to cerebrospinal fluid (CSF) AD biomarkers remains limited.

methodsWe analyzed 854 female participants from the European Prevention of Alzheimer's Dementia Longitudinal Cohort Study with baseline serum estradiol and estrone measured by liquid chromatography-tandem mass spectrometry and repeated CSF amyloid-beta 42 (Aβ

resultsNeither hormone was associated with Aβ DISCUSSION: Findings suggest more consistent cross-sectional associations of estradiol with tau than with Aβ

Indexed as

Alzheimer DiseaseEstradiolEstroneAgedAmyloid beta-PeptidesApolipoprotein E4BiomarkersCohort StudiesCross-Sectional StudiesEuropeFemaleHumansLongitudinal StudiesMiddle AgedPeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)Apolipoprotein E4BiomarkersEstradiolEstronePeptide Fragmentstau ProteinsAlzheimer's diseaseamyloidAPOECSF biomarkersestradiolestrogenestronetauwomen's health

Identifiers

PMID42733033
PMCPMC13572576

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.