ArticleNature communications2026
Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Understanding how cellular architecture shapes cortical function requires mesoscopic approaches that resolve structure-function relationships in vivo. Here we introduce the cerebral blood flow (CBF) - cell-body staining intensity (CSI) similarity index (CCSI), a quantitative measure of laminar perfusion-cytoarchitecture coupling derived from whole-brain 1-mm isotropic 7 T arterial spin labeling and cell-body staining intensity profiles from the BigBrain atlas. Across 30 participants, CCSI revealed reproducible, region-specific alignment between laminar perfusion and cellular density distributions. CCSI was selectively associated with mitochondrial respiratory capacity per mitochondrion and colocalized with capillary endothelial and end-state oligodendrocyte populations. Gene ontology enrichment converged on metabolic regulation, neurovascular organization, and mitochondrial homeostasis. A parallel control analysis using quantitative T1 yielded no significant associations, supporting the specificity of these findings. At the systems level, CCSI improved structure-function gradient correspondence in higher-hierarchy association cortices. These results support CCSI as a reproducible, non-invasive mesoscopic index linking cortical perfusion, microstructure, and metabolism.
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