ArticlePsychopharmacology2026
Topiramate effects on ethanol and sucrose binge-like intake, anxiety- and compulsive-like behavior in non-dependent male and female C57BL/6J mice.
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleRepetitive binge episodes are early-stage patterns in the addiction cycle associated with elevated anxiety and compulsive traits. Despite their high comorbidity and the growing off-label use of topiramate for binge-related disorders, its effects in non-dependent individuals remain poorly characterized and studies systematically comparing both sexes under identical experimental conditions remain scarce.
objectivesTo evaluate the effects of topiramate on ethanol (EtOH) and sucrose binge-like intake, anxiety- and compulsive-like responses in non-dependent male and female C57BL/6J mice.
methodsEtOH (20% v/v) and sucrose (10% w/v) binge-like intake were assessed in a standard Drinking in the Dark (DID) procedure following intraperitoneal topiramate (0, 30, or 60 mg/kg). Blood EtOH concentrations (BECs) were determined after EtOH DID. Anxiety-like and compulsive-like behaviors were assessed using the Elevated Plus Maze (EPM) and Marble Burying (MB) test.
resultsTopiramate significantly reduced EtOH binge-like intake at 60 mg/kg and BECs at 30 and 60 mg/kg, while males consumed more EtOH and showed higher BECs than females. Topiramate did not significantly alter sucrose binge-like intake, with females consuming less sucrose than males. Topiramate significantly reduced anxiety-like behavior in the EPM regardless of sex. In the MB test, the topiramate effect differed significantly across sexes, although these results most likely reflect a floor effect in vehicle-treated females.
conclusionsThese findings provide preliminary evidence that topiramate reduces EtOH binge-like intake, anxiety- and compulsive-like behavior in non-dependent mice with a non-significant attenuation of sucrose binge-like intake. Further research is warranted to establish the translational relevance and to evaluate the preventive potential of topiramate in binge-related disorders.
Indexed as
Identifiers
42733100What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.