Evidence map›Paper›PMID 42733503›Full record

ArticleCurrent developments in nutrition2026

Rationale and Design of Traditional and Adaptive Calorie Restriction and Time-Restricted Eating Interventions Used in the Dietary Approaches to Longevity and Health (DiAL Health) Pilot Trial.

Samantha F Kennedy, Hannah E Cabre, Hanim E Diktas, Kaja Falkenhain, Katherine E Spring, Courtney M Peterson, Gareth R Dutton, Kimberly L Drews, Stephanie T Broyles, Robert Dubin and 9 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current developments in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05549362 (Dietary Approaches to Longevity and Health), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05549362 naactive not recruitingnot on this map

Dietary Approaches to Longevity and Health

TypeinterventionalSponsorPennington Biomedical Research CenterRan2022 to 2025Enrolled90ConditionsAging, Weight Loss, Treatment AdherenceArmsDial Health Research Study
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Samantha F KennedyPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Hannah E CabrePennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Hanim E DiktasPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Kaja FalkenhainPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Katherine E SpringPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Courtney M PetersonDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, United States.
Gareth R DuttonUniversity of Alabama at Birmingham Heersink School of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Kimberly L DrewsPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Stephanie T BroylesPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Robert DubinPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Laura Q RogersUniversity of Alabama at Birmingham Heersink School of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Catherine M ChampagnePennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Dennis T VillarealDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX, United States.
Daniel S HsiaPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Peter G JacobsDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, United States.
Jack RejeskiDepartment of Health and Exercise Sciences, Wake Forest University, Winston-Salem, NC, United States.
Jason FanningDepartment of Health and Exercise Sciences, Wake Forest University, Winston-Salem, NC, United States.
Leanne M RedmanPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.
Corby K MartinPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Research shows that dietary interventions improve biomarkers of health span and aging. Objective: This paper describes the implementation and data collection methods for 4 dietary interventions and a control condition comprising the 5 arms of the Dietary Approaches to Longevity and Health (DiAL Health) Pilot study. Methods: DiAL Health is a 24-wk, randomized controlled pilot trial comparing the feasibility and preliminary efficacy of traditional and adaptive approaches to calorie restriction (CR) and time-restricted eating (TRE) on biomarkers of biological aging and health span in young, healthy adults [age: 25-49 y, body mass index (BMI): 22.0-29.9 kg/m Conclusions: Findings from the DiAL Health Pilot study will inform the design and implementation of a future 5-y clinical trial evaluating personalized dietary strategies to promote longevity and improve health span.This trial was registered at clinicaltrials.gov as NCT05549362.

Indexed as

agingcaloric restrictionfeasibilityhealthspanhealthy agingintermittent fastingJust-in-Time Adaptive InterventionlifespanmHealthtime-restricted eating

Identifiers

PMID42733503
PMCPMC13571450

What Socratic holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.