ArticleiScience2026
Self-rolling film for
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy is a cornerstone of cancer treatment; however, despite major technological advances, radiation-induced injury to surrounding healthy tissues remains a significant clinical challenge. Here, we developed a preclinical rat model of radiation proctitis using localized, fractionated colorectal irradiation followed by comprehensive histopathological characterization. To enable local drug delivery while minimizing systemic exposure, we engineered a self-rolling bilayer PEG-PLA film loaded with the anti-inflammatory drug prednisolone. The biomaterial was optimized for endoscopic implantation into the irradiated colorectum, providing a minimally invasive therapeutic approach. Local administration of prednisolone significantly reduced the secretion of pro-inflammatory cytokines, including IL-1β, within the colonic mucosa, demonstrating the efficacy of the device in attenuating radiation-induced inflammation. Beyond prednisolone delivery, this adaptable platform could support localized administration of a broad range of therapeutic agents, including biologics or other compounds whose systemic use is limited by toxicity, poor tolerability, or high cost.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.