Evidence map›Paper›PMID 42733838›Full record

ArticleiScience2026

Levocarnitine attenuates diabetic seminal vesicle fibrosis in association with improved lipid metabolism and reduced ER stress.

Pengfei Liu, Yi Yu, Junjie Wu, Lei Wang, Fan Yao, Xueqin Chen, Kerong Wu, Xuejun Shang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pengfei LiuDepartment of Urology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yi YuDepartment of Urology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.
Junjie WuDepartment of Urology, Nanjing University of Chinese Medicine Jinling Clinical Medical College, Nanjing, China.
Lei WangSoutheast University Medical College, Nanjing, China.
Fan YaoDepartment of Urology, Nanjing University of Chinese Medicine Jinling Clinical Medical College, Nanjing, China.
Xueqin ChenCenter for Reproductive Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Kerong WuCenter for Reproductive Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Xuejun ShangDepartment of Urology, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seminal vesicle integrity supports semen composition and sperm function, whereas type 2 diabetes mellitus can induce atrophy and fibrosis in this organ. Using a high-fat diet/streptozotocin-induced model in male mice and primary mouse seminal vesicle epithelial cells exposed to high glucose, we assessed fibrotic remodeling, lipid metabolism, PPARα/PGC-1α signaling, endoplasmic reticulum stress, and apoptosis through histological, biochemical, and lipidomic analyses. Diabetic seminal vesicles showed atrophy and fibrosis together with altered lipid profiles, free fatty acid accumulation, reduced PPARα/PGC-1α expression, and increased IRE1-associated stress and apoptosis. Levocarnitine attenuated these changes

Indexed as

endoplasmic reticulum stressfibrosislevocarnitinelipid metabolismseminal vesicletype 2 diabetes mellitus

Identifiers

PMID42733838
PMCPMC13571653

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.