Evidence map›Paper›PMID 42733865›Full record

ArticleiScience2026

Trop-1/EpCAM Thr115 is a driver of hyperproliferative cell repair and of severe lung damage in COVID-19.

Margherita Baldassarri, Marco Trerotola, Giulia Brunelli, Noemi La Francesca, Laura Bergantini, Benedetta Tella, Giulia Rollo, Cecilia Altemura, Vera Giacomazzi, Emanuela Guerra and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Margherita BaldassarriMedical Genetics, University of Siena, 53100 Siena, Italy.
Marco TrerotolaCenter for Advanced Studies and Technologies (CAST), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Giulia BrunelliMedical Genetics, University of Siena, 53100 Siena, Italy.
Noemi La FrancescaSection of Pathology, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Laura BergantiniRespiratory Disease Unit, Department of Medical Sciences, University Hospital of Siena (Azienda Ospedaliera Universitaria Senese, AOUS), 53100 Siena, Italy.
Benedetta TellaMedical Genetics, University of Siena, 53100 Siena, Italy.
Giulia RolloMedical Genetics, University of Siena, 53100 Siena, Italy.
Cecilia AltemuraMedical Genetics, University of Siena, 53100 Siena, Italy.
Vera GiacomazziMedical Genetics, University of Siena, 53100 Siena, Italy.
Emanuela GuerraCenter for Advanced Studies and Technologies (CAST), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Martina CeciCenter for Advanced Studies and Technologies (CAST), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Ludovica PantaloneCenter for Advanced Studies and Technologies (CAST), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Samantha MinettoMedical Genetics, University of Siena, 53100 Siena, Italy.
Elena BargagliRespiratory Disease Unit, Department of Medical Sciences, University Hospital of Siena (Azienda Ospedaliera Universitaria Senese, AOUS), 53100 Siena, Italy.
Cristoforo PomaraDivision of Legal Medicine, University of Catania, 95100 Catania, Italy.
Rossano LattanzioCenter for Advanced Studies and Technologies (CAST), University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Antonino MoschellaUnit of Medical Genetics, Department of Biomedical Sciences-BIOMORF, University of Messina, 98125 Messina, Italy.
Federica Maria PreviteraUnit of Medical Genetics, Department of Biomedical Sciences-BIOMORF, University of Messina, 98125 Messina, Italy.
Cristiana BellanSection of Pathology, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Network for Italian Genomes
GEN-COVID Multicenter Study
Alessandra RenieriMedical Genetics, University of Siena, 53100 Siena, Italy.
Chiara FalleriniMedical Genetics, University of Siena, 53100 Siena, Italy.
Saverio AlbertiUnit of Medical Genetics, Department of Biomedical Sciences-BIOMORF, University of Messina, 98125 Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 lung infection triggers an acute reaction that can severely impair oxygen exchange. However, the underlying molecular processes are poorly understood. The

Indexed as

COVID-19lung epithelial repairlung inflammationTROP1/EPCAM M115T polymorphism

Identifiers

PMID42733865
PMCPMC13571695

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.